INS 365
INS 365
- CAS:
- 211427-08-6
- MF:
- C18H27N4NaO23P4
- MW:
- 814.3
Suppliers by country/region
Company Type
Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO:1.0(Max Conc. mg/mL);1.14(Max Conc. mM)
Water:100.0(Max Conc. mg/mL);113.86(Max Conc. mM)
- form
- A solid
- color
- White to off-white
Safety Information
- Symbol(GHS)
GHS07,GHS02
- Signal word
- Warning
- Hazard statements
- H315-H319-H228
- Precautionary statements
- P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313
Use
Diquafosol (INS-365) was approved in Japan in 2010 as a 3% ophthalmic solution for treatment of dry eye disease. Clinical diagnosis of dry eye is difficult because the condition presents a variety of symptoms. Treatment options include tear supplements (lubricants), anti-inflammatory drugs (e.g., cyclosporine eye drops or steroid eye drops), and tear retention devices. Diquafosol is a unique agent for the treatment of dry eye in that it acts as a P2Y2 purinergic receptor agonist with the ability to activate this receptor on the ocular surface and stimulate water, lipid, and mucin secretion. Diquafosol is metabolized by phosphodiesterases to UTP, UDP, UMP, and uridine. Diquafosol has been well tolerated in clinical trials, with side effects being local to the ocular surface.In addition,no serious ocular or systemic adverse drug reactions were found during the clinical trials.
1 India supplier list of "INS 365"
- Product Name:DiquafosolTetrasodium
- Products Intro:Brand:clearsynth | Product Number:CS-L-00029
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:INS 365
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:DiquafosolTetrasodium
- Products Intro:Brand:pharmaffiliates | Product Number:PA3140000
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:tetrasodium;[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate
- Products Intro:Purity: 98% | Package: 1g,10g,25g,500g,1kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 528-94-9,AMMONIUM SALICYLATE,Linolenic acid,463-40-1,931-36-2
- Product Name: Diquafosol
- Products Intro:Purity: 99 | CustNote: 300G
- Company Type: Trader
- Country/Region: CHINA
- Product Name:TIANFUCHEM--211427-08-6 INS 365
- Products Intro:Purity: 99% | Package: 25KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:DIquafosol (tetrasodium)
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:Diquafosol tetrasodium
- Products Intro:Package: 50mg | CustNote: BOC Sciences also provides custom synthesis services for Diquafosol tetrasodium.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:Diquafosol sodium
- Products Intro:Purity: 97%-99% | Package: 1KG;6.6USD
- Company Type: Trader
- Country/Region: CHINA
$6.60/ 1KG
- Product Name:Diquafosol tetrasodium
- Products Intro:Purity: 0.99 | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA