Losartan Carboxaldehyde
Losartan Carboxaldehyde
- CAS:
- 114798-36-6
- MF:
- C22H21ClN6O
- MW:
- 420.89
Suppliers by country/region
Company Type
Properties
- Melting point:
- 84-86°C
- Boiling point:
- 666.7±65.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator, Under Inert Atmosphere
- solubility
- Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.16±0.10(Predicted)
- color
- Off-White to Light Yellow
Safety Information
- HS Code
- 2933290000
Use
Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.[Cayman Chemical]
6 India supplier list of "Losartan Carboxaldehyde"
- Product Name:Losartan EP Impurity-K
- Products Intro:Purity: 98% | Package: 50 MG; 100 MG; 250 MG ; 3.4 GM
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Losartan EP Impurity K
- Products Intro:Purity: 98% | Package: 25mg, 50mg,100mg,200mg
- Company Type: Manufacturer
- Country/Region: Mumbai,INDIA
- Product Name:Losartan EP Impurity K Losartan USP RC C ; Losartan Aldehyde ; 2-Butyl-4-chloro-1-[p- (o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-formaldehyde
- Products Intro:Purity: 96% | Package: 25 mg, 50 mg , 100mg or 500 mg
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Losartan carboxaldehyde
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Losartan carboxaldehyde
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:LosartanPotassiumEPImpurityK
- Products Intro:Brand：clearsynth | Product Number：CS-T-31265 | Purity：>98%
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:LosartanEPImpurityK
- Products Intro:Brand:synzeal | Product Number:583587536
- Company Type: Trader
- Country/Region: Gujarat,INDIA
- Product Name:LosartanAldehyde
- Products Intro:Brand:pharmaffiliates | Product Number:PA1228110
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:Losartan Carboxaldehyde
- Products Intro:Purity: 0.97 | Package: mgs,gs,kgs | CustNote: A898947
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:Losartan Carboxaldehyde
- Products Intro:Purity: As coa | Package: As request | CustNote: 114798-36-6
- Company Type: Trader
- Country/Region: CHINA