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Losartan Carboxaldehyde

Losartan Carboxaldehyde Structure
CAS No.
114798-36-6
Chemical Name:
Losartan Carboxaldehyde
Synonyms
DUP 167;EXP 3179;Losartan Aldehyde;Losartan EP IMpurity K;Losartan Carboxaldehyde;Losartan Impurity K (EP);Losartan Carboxaldehyde-d3;Losartan Related CoMpound C;Losartan USP Related Compound C;Allisartan Isoproxil impurity II
CBNumber:
CB01176401
Molecular Formula:
C22H21ClN6O
Molecular Weight:
420.89
MOL File:
114798-36-6.mol
Modify Date:
2024/4/1 18:08:31
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Losartan Carboxaldehyde Properties

Melting point 84-86°C
Boiling point 666.7±65.0 °C(Predicted)
Density 1.34±0.1 g/cm3(Predicted)
storage temp. Refrigerator, Under Inert Atmosphere
solubility Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form Solid
pka 4.16±0.10(Predicted)
color Off-White to Light Yellow
CAS DataBase Reference 114798-36-6

SAFETY

Risk and Safety Statements

HS Code  2933290000

Losartan Carboxaldehyde Chemical Properties,Uses,Production

Description

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.

Chemical Properties

Yellow Solid

Uses

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.[Cayman Chemical]

Losartan Carboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

N-Trityl Losartan Carboxaldehyde

Losartan Carboxaldehyde Suppliers

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114798-36-6(Losartan Carboxaldehyde)Related Search:

Losartan carboxylic acid N2-Losartanyl-losartan (Losartan IMpurity) Losartan IsoMer IMpurity, PotassiuM Salt 2'-[(1H-Tetrazol-5-yl)biphenyl-4-yl]Methanol N1-Losartanyl-losartan (Losartan IMpurity)
Triphenylmethanol 2-Butyl-4-chloro-5-formylimidazole Losartan Impurity D 5-(4'-((2-butyl-4-chloro-5-(isopropoxymethyl)-1H-imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-yl)-1H-tetrazole (2-BUTYL-5-CHLORO-1H-IMIDAZOL-4-YL)METHANOL
5-[2-(4'-METHYLBIPHENYL)]TETRAZOLE Losartan IMpurity C (Isolosartan) O-Acetyl Losartan Losartan potassium Losartan
Losartan Carboxaldehyde AKOS 91711 AKOS 91707
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2-Butyl-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde DUP 167 EXP 3179 Losartan Carboxaldehyde Discontinued see product # L470505 Losartan Carboxaldehyde 2-(Butyl-d3)-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde Losartan Carboxaldehyde-d3 Losartan EP IMpurity K (LosaratnCarboxaldehyde) Losartan EP IMpurity K Losartan Related CoMpound C Losartan Aldehyde 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde Losartan Related Compound C (2-Butyl-4-chloro-1-[[2''-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imi (1370495) Losartan Carboxaldehyde_x000b_Discontinued see product # L470505 Losartan EP Impurity K/ Losartan Related Compound C (Losartan Aldehyde) Allisartan Isoproxil impurity II 1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- Losartan EP Impurity K:Losartan Impurity K Losartan Impurity 11(Losartan EP Impurity K) 2-Butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-formaldehyde Losartan Impurity K (EP) 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carbaldehyde Losartan EP Impurity K (Losartan Carboxaldehyde) Losartan USP Related Compound C DuP 167,EXP-3179,DuP-167,Inhibitor,COX,AT1-R–blocking,intermediate aldehyde metabolite,Cyclooxygenase,COX-2,EXP3179,inhibit,EXP 3179,Losartan,Losartan Carboxaldehyde,anti-inflammatory,DuP167 Losartan Potassium EP Impurity K Losartan EP Impurity K (Losartan USP Related Compound C, Losartan Carboxaldehyde) Losartan EP Impurity K Losartan USP RC C 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde 114798-36-6 14798-36-6 C22H21ClN6O Intermediates & Fine Chemicals Isotope Labelled Compounds Metabolites & Impurities Pharmaceuticals Isotope Labeled Compounds