N-Methylleukotriene C4
N-Methylleukotriene C4
- CAS:
- 131391-65-6
- MF:
- C31H49N3O9S
- MW:
- 639.81
Suppliers by country/region
Properties
- Boiling point:
- 965.7±65.0 °C(Predicted)
- Density
- 1.202±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; Ethanol:H20 (95:5): 2 mg/ml; PBS (pH 7.2): 100 μg/ml
- pka
- 2.23±0.10(Predicted)
Safety Information
Use
Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively. It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.
0 India supplier list of "N-Methylleukotriene C4"
- Product Name:N-Methylleukotriene C4
- Products Intro:Purity: 97%
- Company Type: Reagent
- Country/Region: UNITED STATES
- Main Products: Active Pharmaceutical Ingredient (API),Insect Pheromone,Boronic Compounds,Material & Chemicals,Lipid Compounds
-
25 μg$134.0050 μg$255.00100 μg$482.00
- Product Name:N-methyl Leukotriene C4
- Products Intro:Brand: Caymanchem | Product Number: 13390 | Purity: ≥97%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: cof,mof
- Product Name:N-MethylleukotrieneC4
- Products Intro:Brand：a2bchem | Product Number：AE34843
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:N-MethylleukotrieneC4
- Products Intro:Brand：aksci | Product Number：1939AH
- Company Type: Trader
- Country/Region: UNITED STATES
-
2.5mg$1340.005mg$2535.00
- Product Name:N-methylLeukotrieneC4
- Products Intro:Brand:trc-canada | Product Number:L330388
- Company Type: Trader
- Country/Region: CANADA
- Product Name:N-methyl Leukotriene C4
- Company Type: Reagent
- Country/Region: UNITED STATES
- Product Name:N-methyl Leukotriene C4
- Company Type: Trader
- Country/Region: CHINA
- Product Name:N-methyl Leukotriene C4
- Company Type: Trader
- Country/Region: CHINA
- Product Name:N-methyl Leukotriene C4
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:N-methyl Leukotriene C4
- Products Intro:Purity: 97% | Package: 25μg;50μg;100μg
- Company Type: Trader
- Country/Region: CHINA