α-Naphthoflavone
α-Naphthoflavone
- CAS:
- 604-59-1
- MF:
- C19H12O2
- MW:
- 272.3
Suppliers by country/region
Company Type
Properties
- Melting point:
- 153-157 °C (lit.)
- Boiling point:
- 375.35°C (rough estimate)
- Density
- 1.1382 (rough estimate)
- refractive index
- 1.5510 (estimate)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Crystalline Powder or Crystals
- color
- yellow
- BRN
- 210862
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- LogP
- 5.003 (est)
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H413
- Precautionary statements
- P264-P270-P273-P301+P312-P330
- Hazard Codes
- Xi,Xn,C,F
- Risk Statements
- 68-34-11
- Safety Statements
- 24/25-36/37-45-36/37/39-26-16
- WGK Germany
- 3
- RTECS
- QL6250000
- F
- 8
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 29143990
Use
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. α-Naphthoflavone is a flavone that modulates xenobiotic metabolism at several points. It antagonizes AhR, blocking the expression of phase I and II genes at nanomolar concentrations, although it can agonize AhR at higher concentrations (10 μM). α-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 μM). Dietary α-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens.[Cayman Chemical]
7 India supplier list of "α-Naphthoflavone"
- Product Name:alpha-Naphthoflavone
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:alpha-Naphthoflavone
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Alpha-Naphthoflavone(7,8-Benzoflavone)
- Products Intro:Purity: 98% | Package: 1 kg, 5 kg, 10 kg, 25 kg and 100 kg
- Company Type: Trader
- Country/Region: Tamil Nadu,INDIA
- Product Name:Alpha-Naphthoflavone
- Products Intro:Purity: 98% | Package: 1 kg, 5 kg, 10 kg, 25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:α-Naphthoflavone
- Products Intro:Brand:sigma aldrich | Product Number:N5757 | Purity:≥98%
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Alpha-naphthoflavone 95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.157844
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:α-Naphthoflavone
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:α-Naphthoflavone
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:alpha-Naphthoflavone,97%
- Products Intro:Brand:chemsworth | Product Number:718216661
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:a-NaphthoflavoneextrapureAR,98%
- Products Intro:Brand:trivenichemical | Product Number:57955
- Company Type: Trader
- Country/Region: New Delhi,INDIA