NOGALAMYCIN
NOGALAMYCIN
- CAS:
- 1404-15-5
- MF:
- C39H49NO16
- MW:
- 787.8
Suppliers by country/region
Company Type
Properties
- Melting point:
- 195-196° (dec)
- alpha
- D25 +425° (c = 0.11 in CHCl3)
- Boiling point:
- 658.61°C (rough estimate)
- Density
- 1.2095 (rough estimate)
- refractive index
- 1.7650 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMF: Soluble; DMSO: Soluble; Ethanol: soluble; Methanol: Soluble
- form
- A solid
- pka
- 7.45 (60% ethanol)
- color
- Orange-red solid from MeOH
Safety Information
- Symbol(GHS)
GHS07,GHS08
- Signal word
- Danger
- Hazard statements
- H302-H312-H332-H350-H360
- Precautionary statements
- P201-P280-P308+P313
- Hazard Codes
- T
- Risk Statements
- 45-46-61-20/21/22
- Safety Statements
- 53-22-36/37/39-45
- WGK Germany
- 3
- RTECS
- RA4550000
- Toxicity
- LD50 in mice (mg/kg): 11.75 i.v., 4.79 i.p. (Hadidian)
Use
Nogalamycin is an unusual anthracycline produced by Streptomyces nogalater var. nogalater, reported by researchers at Upjohn in 1965. Nogalamycin contains two saccharides. The neutral monosaccharide attaches to the D ring, similar to the aminoglycoside moieties of the doxorubicin class, while the second, basic saccharide attaches to the phenolic group on the A ring in the ortho position to form a unique family of hexacyclic anthracyclines. Nogalamycin is potent antibacterial and antitumor agent that interacts with DNA by intercalation.
0 India supplier list of "NOGALAMYCIN"