Paricalcitol manufacturers and suppliers in india

Paricalcitol

Properties

Boiling point:: 564.8±50.0 °C(Predicted)

Density: 1.121±0.06 g/cm3(Predicted)

Flash point:: 14℃

storage temp.: Store at -20°C,unstable in solution, ready to use.

solubility: DMSO : 100 mg/mL (240.02 mM; Need ultrasonic)Ethanol : 12.5 mg/mL (30.00 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)

pka: 14.34±0.40(Predicted)

form: Solid

color: White to off-white

InChIKey: BPKAHTKRCLCHEA-UBFJEZKGSA-N

SMILES: C[C@]12CCC/C(=C\C=C3C[C@@H](O)C[C@H](O)C3)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(O)(C)C |&1:1,10,13,16,20,22,26,r|

Safety Information

Symbol(GHS): GHS06,GHS08

Signal word: Danger

Hazard statements: H301+H311-H330-H372

Precautionary statements: P280-P301+P310+P330-P302+P352+P312-P304+P340+P310-P314

RIDADR: UN1170 - class 3 - PG 2 - Ethanol, solution

HS Code: 2936299055

Use

Paricalcitol was launched as Zemplar in the US for the prevention and treatment of secondary hyperthyroidism associated with chronic renal failure. Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue in which the ring A exocyclic methylene group, typical of all vitamin D systems, has been replaced by two hydrogen atoms. Paricalcitol is the first vitamin D analogue marketed for this indication. In patients with chronic renal failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH) without a significant difference in the incidence rate for hypercalcemia or hyperphosphatemia when compared with placebo.