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PHENCYCLIDINE
PHENCYCLIDINE
- CAS:
- 77-10-1
- MF:
- C17H25N
- MW:
- 243.39
Properties
- Melting point:
- 46.5℃
- Boiling point:
- bp1.0 135-137°
- Density
- 0.9762 (rough estimate)
- refractive index
- 1.5000 (estimate)
- Flash point:
- 11 °C
- storage temp.
- −20°C
- pka
- pKa 8.5 (Uncertain)
- color
- Colorless crystals
Safety Information
- Symbol(GHS)
GHS02,GHS06,GHS08
- Signal word
- Danger
- Hazard statements
- H225-H301+H311+H331-H370
- Precautionary statements
- P210-P260-P280-P301+P310-P311
- Hazard Codes
- F,T
- Risk Statements
- 23/24/25-39/23/24/25-11-61
- Safety Statements
- 36/37-45-16-53
- RIDADR
- 2811
- WGK Germany
- 1
- HazardClass
- 6.1(a)
- PackingGroup
- I
- Toxicity
- LD50 oral in mouse: 75mg/kg
Use
Phencyclidine was introduced as a dissociative anestheticfor animals. Its close structural relative ketamine is still soused and may be used in humans. In humans,PCP produces a sense of intoxication, hallucinogenic experiencesnot unlike those produced by the anticholinergic hallucinogens,and often, amnesia.The drug affects many systems, including those of NE,DA, and 5-HT. It has been proposed that PCP (and certainother psychotomimetics) produces a unique pattern of activationof ventral tegumental area dopaminergic neurons.Itblocks glutaminergic N-methyl-D-aspartate receptors.Thisaction is the basis for many of its CNS effects. PCP itself appearsto be the active agent. The psychotic state produced bythis drug is also cited as a better model than amphetaminepsychosis for the psychotic state of schizophrenia.
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