Phenylephrine manufacturers and suppliers in india

Phenylephrine

Properties

Melting point:: 171°C

Boiling point:: 295.79°C (rough estimate)

Density: 1.1222 (rough estimate)

refractive index: -55.5 ° (C=5, 1mol/L HCl)

storage temp.: -20°C Freezer, Under inert atmosphere

solubility: Slightly soluble in water, sparingly soluble in methanol, slightly soluble in ethanol (96 per cent). It dissolves in dilute mineral acids and in dilute solutions of alkali hydroxides.

form: Solid

pka: pKa 8.9 (Uncertain)

color: White to Off-White

Safety Information

Symbol(GHS): GHS05,GHS07

Signal word: Danger

Hazard statements: H302-H315-H318-H335

Precautionary statements: P261-P264-P280-P301+P312-P302+P352-P305+P351+P338

Hazard Codes: Xn

Risk Statements: 22-36/37/38-41-37/38

Safety Statements: 26-36-45-39

RTECS: DO7175000

HS Code: 2922.19.7000

Toxicity: LD50 oral in rat: 350mg/kg

Use

L-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 μM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 μM, respectively). By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine. This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents. Because L-phenylephrine acts on adrenergic α1 receptors in the arterioles of the nasal mucosa to produce constriction, it has been examined clinically as an oral decongestant.