Podophyllotoxin
Podophyllotoxin
- CAS:
- 518-28-5
- MF:
- C22H22O8
- MW:
- 414.41
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Properties
- Melting point:
- 183-184 °C (lit.)
- alpha
- -110.7 º (c=1, CHCl3)
- Boiling point:
- 453.31°C (rough estimate)
- Density
- 1.2649 (rough estimate)
- refractive index
- 1.4480 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO:15.0(Max Conc. mg/mL);36.2(Max Conc. mM)
- pka
- 13.26±0.40(Predicted)
- form
- Powder
- color
- White to off-white
- optical activity
- [α]/D 131±2°, c = 1 in chloroform
- Merck
- 13,7628
- BRN
- 99163
- Stability:
- Very Hygroscopic
- InChIKey
- YJGVMLPVUAXIQN-XVVDYKMHSA-N
- LogP
- 2.010
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H301+H311+H331-H315-H319-H335
- Precautionary statements
- P261-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338
- Hazard Codes
- T
- Risk Statements
- 21-25-36/37/38-23/25-23/24/25
- Safety Statements
- 36/37/39-45-26
- RIDADR
- UN 3462 6.1/PG 2
- WGK Germany
- 3
- RTECS
- LV2500000
- F
- 1-8-10
- HazardClass
- 6.1(a)
- PackingGroup
- II
- HS Code
- 29189090
- Toxicity
- LD50 in rats (mg/kg): 8.7 i.v.; 15 i.p. (Phillips)
Use
Podophyllotoxin is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species. It binds to topoisomerase II during the late S and early G2 stage, blocking tubulin polymerization and, thus, inhibiting mitosis. In addition to being used as a cathartic, purgative, antiviral agent, vesicant, and antihelminthic, podophyllotoxin is the starting material for the semi-synthesis of the anti-cancer drugs etoposide , teniposide , and etopophos.
10 India supplier list of "Podophyllotoxin"
- Product Name:Etoposide EP Impurity-M
- Products Intro:Purity: 98% | Package: 50 MG; 100 MG; 250 MG ; 200 MG
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Podophyllotoxin
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Podophyllotoxin
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Reagent
- Country/Region: Himachal Pradesh,INDIA
- Product Name:Podophyllotoxin
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Punjab,INDIA
- Product Name:Podophyllotoxin
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Podophyllotoxin
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: AndhraPradesh,INDIA
- Product Name:Podophyllotoxin
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Haryana,INDIA
- Product Name:Podophyllotoxin
- Products Intro:Brand:sigma aldrich | Product Number:P4405
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Podophyllotoxin 98% (HPLC)
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.039385
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Podophyllotoxin
- Company Type: Trader
- Country/Region: New Delhi,INDIA