R-406
R-406
- CAS:
- 841290-80-0
- MF:
- C22H23FN6O5
- MW:
- 470.45
Suppliers by country/region
Company Type
Properties
- Melting point:
- 182-184°C
- Density
- 1.358±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 10.63±0.40(Predicted)
- color
- Off-White to Light Grey
Safety Information
- Symbol(GHS)
GHS08,GHS06
- Signal word
- Danger
- Hazard statements
- H301-H361
- Precautionary statements
- P264-P270-P301+P310-P321-P330-P405-P501-P201-P202-P281-P308+P313-P405-P501
Use
R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcεRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 μM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce immune complex-mediated inflammation. In cancers characterized by over-expression of Syk, R406 can prevent signaling downstream of Syk and induce apoptosis. R406 also inhibits Syk-dependent signaling through c-Jun N-terminal kinase in rheumatoid arthritis synoviocytes, suggesting a therapeutic intervention in this autoimmune disease.[Cayman Chemical]
1 India supplier list of "R-406"
- Product Name:R406 >95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.089152
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Tamatinib
- Products Intro:Brand:clearsynth | Product Number:CS-T-94009
- Company Type: Trader
- Country/Region: INDIA
- Product Name:R406
- Products Intro:Brand:ajchemicals | Product Number:JDH-36064 | Purity:98+%
- Company Type: Trader
- Country/Region: INDIA
- Product Name:R-406
- Products Intro:Purity: 98%(Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:R-406
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:R406
- Products Intro:Package: 25 mg | CustNote: BOC Sciences also provides custom synthesis services for R406.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:r-406
- Products Intro:Purity: 0.99 | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:R406 free base
- Products Intro:Purity: 0.99 | Package: 1KG;5KG;100KG;1000KG | CustNote: 1KG,5KG,25KG,200KG
- Company Type: Trader
- Country/Region: CHINA