RADICICOL
RADICICOL
- CAS:
- 12772-57-5
- MF:
- C18H17ClO6
- MW:
- 364.78
Suppliers by country/region
Company Type
Properties
- Melting point:
- 193.5°
- alpha
- D20 +203° (chloroform)
- Boiling point:
- 656.2±55.0 °C(Predicted)
- Density
- 1.364±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- ethanol: 10 mg/mL
- form
- solid
- pka
- 6.29±0.40(Predicted)
- color
- yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety Information
- Symbol(GHS)
GHS06,GHS08
- Signal word
- Danger
- Hazard statements
- H301-H340-H350
- Precautionary statements
- P202-P264-P270-P280-P301+P310-P405
- Hazard Codes
- Xn,T
- Risk Statements
- 22-36/37/38-46-45
- Safety Statements
- 26-45-53
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 1
- RTECS
- RR1105000
- HS Code
- 29322090
- Toxicity
- mouse,LD50,intravenous,175mg/kg (175mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 2, Pg. 448, 1980.
Use
Radicicol is a resorcylic acid lactone, produced by several fungal species, that exhibits broad spectrum antifungal and antitumor activity. Radicicol has been the subject of extensive investigation and inhibits protein tyrosine kinase, induces the differentiation of HL-60 cells into macrophages, blocks cell cycle at G1 and G2, suppresses NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos, and also suppresses the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of plasminogen activator production by vascular endothelial cells.
0 India supplier list of "RADICICOL"
- Product Name:Radicicol,Diheterosporachlamydosporia-CAS12772-57-5-Calbiochem
- Products Intro:Brand:sigma aldrich | Product Number:553400
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Radicicol;Monorden
- Products Intro:Purity: 98.00% | Package: 1 mg;10 mg;100 mg;5 mg;50 mg;500 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
-
1 mg$139.00
- Product Name:(1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione
- Products Intro:Brand: Tocris Bioscience | Product Number: 1589 | Purity: ≥98% (HPLC)
- Company Type: Trader
- Country/Region: UNITED KINGDOM
- Main Products: cof,mof