RADICICOL
- CAS No.
- 12772-57-5
- Chemical Name:
- RADICICOL
- Synonyms
- KF9-A;KF58332;FO-4910;MONORDEN;RADICICOL;RADISICOL;RHI-12648;MONORODENE;monorderne;Nsc 294404
- CBNumber:
- CB4165202
- Molecular Formula:
- C18H17ClO6
- Molecular Weight:
- 364.78
- MOL File:
- 12772-57-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 193.5° |
|---|---|
| alpha | D20 +203° (chloroform) |
| Boiling point | 656.2±55.0 °C(Predicted) |
| Density | 1.364±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | ethanol: 10 mg/mL |
| form | solid |
| pka | 6.29±0.40(Predicted) |
| color | yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H340-H350 | |||||||||
| Precautionary statements | P202-P264-P270-P280-P301+P310-P405 | |||||||||
| Hazard Codes | Xn,T | |||||||||
| Risk Statements | 22-36/37/38-46-45 | |||||||||
| Safety Statements | 26-45-53 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | RR1105000 | |||||||||
| HS Code | 29322090 | |||||||||
| Toxicity | mouse,LD50,intravenous,175mg/kg (175mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 2, Pg. 448, 1980. | |||||||||
| NFPA 704 |
|
RADICICOL price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | R2146 | Radicicol from Diheterospora chlamydosporia solid | 12772-57-5 | 1MG | ₹17601.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | R2146 | Radicicol from Diheterospora chlamydosporia solid | 12772-57-5 | 5MG | ₹70449.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 553400 | Radicicol, Diheterospora chlamydosporia - CAS 12772-57-5 - Calbiochem | 12772-57-5 | 500μG | ₹14260 | 2022-06-14 | Buy |
RADICICOL Chemical Properties,Uses,Production
Chemical Properties
Solid
Uses
Radicicol is a resorcylic acid lactone, produced by several fungal species, that exhibits broad spectrum antifungal and antitumour activity. Radicicol has been the subject of extensive investigation and inhibits protein tyrosine kinase, induces the differentiation of HL-60 cells into macrophages, blocks cell cycle at G1 and G2, suppresses NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos, and also suppresses the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of plasminogen activator production by vascular endothelial cells.
Definition
ChEBI: An antifungal macrolactone antibiotic, obtained from Diheterospora chlamydosporia and Chaetomium chiversii that inhibits protein tyrosine kinase and heat shock protein 90 (Hsp90).
Biological Activity
Antifungal antibiotic. Inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis.
RADICICOL Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | China | 25014 | 65 | Inquiry |
| RD International Technology Co., Limited | 18024082417 | China | 9155 | 58 | Inquiry |
| Hubei Nordina Biotechnology Co., Ltd. | 18162687220 18162687220 | China | 2999 | 58 | Inquiry |
| BOC Sciences | USA | 0 | 65 | Inquiry | |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | China | 5014 | 58 | Inquiry |
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