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Tulathromycin A

Tulathromycin A Structure
CAS No.
217500-96-4
Chemical Name:
Tulathromycin A
Synonyms
CS-2009;Draxxin;CP 472295;Teramycin;Tulamycin;Tulathrmycin A;TULATHROMYCIN A;Unii-897A3kn7ap;Tulathromycin A, >=95%;Tulathromycin isomer mix
CBNumber:
CB41011760
Molecular Formula:
C41H79N3O12
Molecular Weight:
806.09
MOL File:
217500-96-4.mol
Modify Date:
2024/6/27 13:31:27
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Tulathromycin A Properties

Melting point 186-188oC
Boiling point 853.8±65.0 °C(Predicted)
Density 1.17
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 13.19±0.70(Predicted)
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319-H412-H317
Precautionary statements  P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P273-P501-P264-P280-P305+P351+P338-P337+P313P
NFPA 704
0
2 0

Tulathromycin A price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML2107 Tulathromycin A ≥95% (HPLC) 217500-96-4 10MG ₹9331.15 2022-06-14 Buy
Sigma-Aldrich(India) SML2107 Tulathromycin A ≥95% (HPLC) 217500-96-4 50MG ₹37660.18 2022-06-14 Buy
Product number Packaging Price Buy
SML2107 10MG ₹9331.15 Buy
SML2107 50MG ₹37660.18 Buy

Tulathromycin A Chemical Properties,Uses,Production

Description

Tulathromycin A, marketed as Draxxin by Pfizer Inc., is a triamide antibiotic used for the treatment of respiratory diseases in cattle and pigs. It exists as a balanced mixture of two isomers, Tulathromycin A (90%) and B (10%). Tulathromycin is an antimicrobial agent of a macrolide, a 15-membered macrolide structure that is considered a triamide macrolide with three charged nitro groups.

Chemical Properties

Tulathromycin is a semi-synthetic macrolide antibiotic of the sub-class triamilide. It occurs as a white to off-white crystalline powder that is readily soluble in water at pH less than 8. At a pH of 7.4 (physiological pH), tulathromycin (a weak base) is 50 times more soluble in hydrophilic than hydrophobic media.

Biological Activity

Tulathromycin, like other macrolides, exerts therapeutic benefits not solely explainable by antibacterial activity. Like azithromycin, tulathromycin A may have multiple immunomodulatory effects that likely contribute to the therapeutic response in respiratory infections and perhaps other diseases[1]. Other beneficial effects may be caused by enhanced degranulation and apoptosis of neutrophils and inhibition of inflammatory cytokine production. It also may help clear infections by enhancing macrophage functions.

Pharmacokinetics

The half-life is long, with 80- to 90-hour plasma half-life in pigs and cattle, and 8- and 6-day tissue half-life in cattle and pigs, respectively, which prolongs the drug concentration at the site of infection. The volume of distribution is greater than 10 L/kg. Absorption from injection is greater than 80% in cattle and pigs. Tulathromycin A concentrates in bronchoalveolar cells, and concentrations are detectable for at least 8 days after a single administration, although they are still lower than the MIC for R. equi (greater than 64 μg/mL)[1-2].

Mode of action

Tulathromycin A is a macrolide antibiotic. It binds to the subunit 50S of the bacterial ribosome, interfering with bacterial protein synthesis.

References

[1] Mark G, et al. Tulathromycin. Papich Handbook of Veterinary Drugs (Fifth Edition), 2021; 949-951.
[2] Jennifer L, et al. Pharmacologic Principles. Equine Internal Medicine (Fourth Edition), 2018; 79-137.

Tulathromycin A Preparation Products And Raw materials

Raw materials

Preparation Products

Tulathromycin A Suppliers

Global( 258)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Sinoway Industrial co., ltd. 0592-5800732; +8613806035118 China 992 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21676 55 Inquiry
Shanghai Time Chemicals CO., Ltd. +86-021-57951555 +8617317452075 China 1807 55 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9338 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Zhejiang ZETian Fine Chemicals Co. LTD +8618957127338 China 2141 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Sinoway Industrial co., ltd. 58
Henan Tianfu Chemical Co.,Ltd. 55
Shanghai Time Chemicals CO., Ltd. 55
Hangzhou FandaChem Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Zhejiang ZETian Fine Chemicals Co. LTD 58

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TULATHROMYCIN A (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-Dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-a-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one Unii-897A3kn7ap (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-Dideoxy-3-C-Methyl-3-O-Methyl-4-C-[(propylaMino)Methyl]-α-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexaMethyl-11-[[3,4,6-trideoxy-3-(diMethylaMino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one CP 472295 Draxxin Tulathromycin A, >=95% Tulathrmycin A Tulathromycin A Solution, 1000ppm Tulathromycin，Tulathromycin A CS-2009 (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-5-(propylaminomethyl)oxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one Tulathromycin isomer mix pharmaceutical ingredient TULATHROMYCIN A 1-Oxa-6-azacyclopentadecan-15-one, 13-[[2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-α-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)- Tulathromycin A USP/EP/BP Tulathromycin A (CP 472295) (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-5-((propylamino)methyl)tetrahydro-2H-pyran-2-yl)oxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one Teramycin Tulamycin 217500-96-4 C41H79N3O12 API Carbohydrates & Derivatives Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals 217500-96-4