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ChemicalBook > Product Catalogue >API >Antibiotics >Other antibiotic Drugs >RADICICOL

RADICICOL

RADICICOL Structure
  • ₹14260 - ₹70449.1
  • Product name: RADICICOL
  • CAS: 12772-57-5
  • MF: C18H17ClO6
  • MW: 364.78
  • EINECS:
  • MDL Number:MFCD06795865
  • Synonyms:(1AR,2Z,4E,14R,15AR)-8-CHLORO-1A,14,15,15A-TETRAHYDRO-9,11-DIHYDROXY-14-METHYL-6H-OXIRENO[E][2]BENZOXACYCLOTETRADECIN-6,12(7H)-DIONE;[1AS-(1AR*,2Z,4E,14*,15AR*)]-8-CHLORO-1A,14,15,15A-TETRAHYDRO-9,11-DIHYDROXY-14-METHYL-6H-OXIRENO[E][2]BENZOXACYCLOTETRADECIN-6,12(7H)-DIONE;5-CHLORO-6-(7,8-EPOXY-10-HYDROXY-2-OXO-3,5-UNDECADIENYL)-BETA-RESORCYLIC ACID MU-LACTONE;FO-4910;KF58332;KF9-A;MONORDEN;MONORODENE
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • 500μG
  • ManufacturerSigma-Aldrich(India)
  • Product number553400
  • Product descriptionRadicicol, Diheterospora chlamydosporia - CAS 12772-57-5 - Calbiochem
  • Packaging500μG
  • Price₹14260
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberR2146
  • Product descriptionRadicicol from Diheterospora chlamydosporia solid
  • Packaging1MG
  • Price₹17601.45
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberR2146
  • Product descriptionRadicicol from Diheterospora chlamydosporia solid
  • Packaging5MG
  • Price₹70449.1
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 553400 Radicicol, Diheterospora chlamydosporia - CAS 12772-57-5 - Calbiochem 500μG ₹14260 2022-06-14 Buy
Sigma-Aldrich(India) R2146 Radicicol from Diheterospora chlamydosporia solid 1MG ₹17601.45 2022-06-14 Buy
Sigma-Aldrich(India) R2146 Radicicol from Diheterospora chlamydosporia solid 5MG ₹70449.1 2022-06-14 Buy

Properties

Melting point :193.5°
alpha :D20 +203° (chloroform)
Boiling point :656.2±55.0 °C(Predicted)
Density :1.364±0.06 g/cm3(Predicted)
storage temp. :−20°C
solubility :ethanol: 10 mg/mL
form :solid
pka :6.29±0.40(Predicted)
color :yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger GHS hazard pictograms
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.

Description

Radicicol is a natural product derived from D. chlamydosporia with antibiotic, antifungal, and antimalarial properties. It binds and inhibits heat shock protein 90 (Hsp90) with nanomolar affinity. This interaction inhibits p23 from associating with Hsp90, suppresses signaling through HIF-1α, and produces decreased levels of progesterone receptor, Raf-1, p185erb82, and mutant p53. Radicicol also binds to and inhibits DNA topoisomerase type II proteins and GRP94 through an ATPase domain common to Hsp90.

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