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ChemicalBook > Product Catalogue >API >Synthetic Anti-infective Drugs >Anti-tuberculous mycobacterium leprae drugs >Thalidomide

Thalidomide

Thalidomide Structure
  • ₹5600 - ₹65080
  • Product name: Thalidomide
  • CAS: 50-35-1
  • MF: C13H10N2O4
  • MW: 258.23
  • EINECS:200-031-1
  • MDL Number:MFCD00153873
  • Synonyms:(+-)-THALIDOMIDE >98% IMMUNOSUPPRESSIVE, SE;N-PHTHALOLYLGLUTAMIMIDE;3-PHTHALIMIDOGLUTARIMIDE;(+/-)-THALIDOMIDE;THALIDOMIDE;(+/-)-N-(2,6-DIOXO-3-PIPERIDINYL)PHTHALIMIDE;N-(2,6-DIOXO-3-PIPERIDINYL)PHTHALIMIDE;N-(2,6-DIOXOPIPERIDIN-3-YL)PHTHALIMIDE
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 100MG
  • 1G
  • 5G
  • ManufacturerTCI Chemicals (India)
  • Product numberT2524
  • Product description(±)-Thalidomide
  • Packaging1G
  • Price₹5600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberT2524
  • Product description(±)-Thalidomide
  • Packaging5G
  • Price₹9800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT144
  • Product description(±)-Thalidomide ≥98%, powder
  • Packaging100MG
  • Price₹9030
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT144
  • Product description(±)-Thalidomide ≥98%, powder
  • Packaging1G
  • Price₹65080
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) T2524 (±)-Thalidomide 1G ₹5600 2022-05-26 Buy
TCI Chemicals (India) T2524 (±)-Thalidomide 5G ₹9800 2022-05-26 Buy
Sigma-Aldrich(India) T144 (±)-Thalidomide ≥98%, powder 100MG ₹9030 2022-06-14 Buy
Sigma-Aldrich(India) T144 (±)-Thalidomide ≥98%, powder 1G ₹65080 2022-06-14 Buy

Properties

Melting point :269-271°C
Boiling point :401.48°C (rough estimate)
Density :1.2944 (rough estimate)
refractive index :1.5300 (estimate)
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.6 mg/mL
form :White solid
pka :10.70±0.40(Predicted)
color :white
Water Solubility :<0.1 g/100 mL at 22 ºC
λmax :300nm(lit.)
Merck :14,9255
Stability :Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey :UEJJHQNACJXSKW-UHFFFAOYSA-N
CAS DataBase Reference :50-35-1(CAS DataBase Reference)
NIST Chemistry Reference :Phthalimide, n-(2,6-dioxo-3-piperidyl)-(50-35-1)
EPA Substance Registry System :Thalidomide (50-35-1)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Thalidomide was prescribed as an anti-nausea agent to help pregnant women with morning sickness in the late 1950s. It was found to be a potent teratogen, causing many different forms of birth defects and was withdrawn from the market. Thalidomide and synthetic analogs have recently been proven effective in treating inflammation associated with diseases such as leprosy, arthritis and Crohn’s disease, and in cancers such as multiple myeloma. The direct target for the teratogenicity of thalidomide was not discovered until 2010, when it was found that it interacts directly with the protein cereblon (CRBN; IC50 = 8.5 nM), a ubiquitously-expressed E3 ligase. Binding of thalidomide analogs to CRBN-DNA damage binding protein-1 complexes account for the immunomodulatory and antiproliferative effects of these compounds.

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Suppliers and manufacturers

PANCHSHEEL ORGANICS LTD Viyash Life Sciences Pvt Ltd Hetero Drugs Limited Shilpa Medicare Limited (SML) HRV Global Life Sciences Sami Sabinsa Group Limited (formerly Sami Labs Limited) Aspen Biopharma Labs Pvt Ltd Symed Laboratories Ltd A.J Chemicals CLEARSYNTH LABS LTD.