RADICICOL manufacturers and suppliers in india

RADICICOL

Properties

Melting point:: 193.5°

alpha: D20 +203° (chloroform)

Boiling point:: 656.2±55.0 °C(Predicted)

Density: 1.364±0.06 g/cm3(Predicted)

storage temp.: −20°C

solubility: ethanol: 10 mg/mL

form: solid

pka: 6.29±0.40(Predicted)

color: yellow

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS06,GHS08

Signal word: Danger

Hazard statements: H301-H340-H350

Precautionary statements: P202-P264-P270-P280-P301+P310-P405

Hazard Codes: Xn,T

Risk Statements: 22-36/37/38-46-45

Safety Statements: 26-45-53

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 1

RTECS: RR1105000

HS Code: 29322090

Toxicity: mouse,LD50,intravenous,175mg/kg (175mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 2, Pg. 448, 1980.

Use

Radicicol is a resorcylic acid lactone, produced by several fungal species, that exhibits broad spectrum antifungal and antitumor activity. Radicicol has been the subject of extensive investigation and inhibits protein tyrosine kinase, induces the differentiation of HL-60 cells into macrophages, blocks cell cycle at G1 and G2, suppresses NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos, and also suppresses the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of plasminogen activator production by vascular endothelial cells.