Radotinib
Radotinib
- CAS:
- 926037-48-1
- MF:
- C27H21F3N8O
- MW:
- 530.5
Suppliers by country/region
Company Type
Properties
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥26.55 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
- form
- solid
- pka
- 12.94±0.70(Predicted)
- color
- Light yellow to yellow
Safety Information
- Symbol(GHS)
GHS05,GHS07,GHS08
- Signal word
- Danger
- Hazard statements
- H302-H315-H318-H334-H317-H341-H361-H370-H335-H413
Use
Radotinib, an inhibitor of Bcr–Abl tyrosine kinase,was approved in January 2012 in Korea as a second-line treatment for chronic myeloid leukemia (CML). Radotinib is a TKI with a similar structure to the second-generation TKI, nilotinib, in which a pyridyl group has been replaced with a pyrazinemoiety. The in vitro activity of radotinib against a variety of tumor cell lines is disclosed in an issued patent. Radotinib was significantly more potent than imatinib in all of the cell lines tested. The synthesis of radotinib via amide coupling is described in the patent literature.
1 India supplier list of "Radotinib"
- Product Name:Radotinib 95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.191165
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Radotinib
- Products Intro:Brand:ajchemicals | Product Number:JDH-36074 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:radotinib
- Products Intro:Brand:clearsynth | Product Number:CS-DV-03672
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:Radotinib;IY5511
- Products Intro:Purity: 98% HPLC | Package: 5MG;10MG;50MG;100MG,1G,5G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:Radotinib
- Products Intro:Purity: >98% | Package: 50mg | CustNote: BOC Sciences also provides custom synthesis services for Radotinib.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:Radotinib
- Products Intro:Purity: 0.99 | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Radotinib IY-5511
- Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: Radotinib IY-5511
- Company Type: Trader
- Country/Region: CHINA
- Main Products: sarms
- Product Name:4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phe...
- Company Type: Manufacturer
- Country/Region: CHINA
- Product Name:Radotinib HCl
- Products Intro:Package: 1g; 5g; 25g; 1kg; 5kg; 25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: pharmaceuticals,intermediates,fine chemicals,screening compounds,building blocks