Rosiglitazone manufacturers and suppliers in india

Rosiglitazone

Properties

Melting point:: 153-155 C

Boiling point:: 585.0±35.0 °C(Predicted)

Density: 1.315±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: DMSO: ≥10mg/mL

pka: 6.34±0.50(Predicted)

form: powder

color: White to Off-White

Merck: 14,8265

Safety Information

Symbol(GHS): GHS08,GHS07,GHS09

Signal word: Warning

Hazard statements: H319-H410-H361

Precautionary statements: P273-P391-P501-P264-P280-P305+P351+P338-P337+P313P-P201-P202-P281-P308+P313-P405-P501

Hazard Codes: Xi

Risk Statements: 36/38

Safety Statements: 26-37/39

WGK Germany: 3

RTECS: XJ5813850

HS Code: 2934100000

Use

Rosiglitazone is a type of thiazolidinedione antidiabetics. Thiazolidinedione are agonists for peroxisome-proliferatoractivated receptor (PPAR-). PPAR- receptors are ligand-activated nuclear transcription factors that modulate gene expression, lowering blood glucose primarily by increasing insulin sensitivity in peripheral tissues. Rosiglitazone is widely used to lower blood glucose levels in patients with type 2 diabetes mellitus. Rosiglitazone functionalizes by makes the cells of the body more sensitive to the naturally produced insulin in body. It shouldnt be used if the patient is injecting or inhaling insulin. Using rosiglitazone with insulin could increase the risk of heart failure. Patients having heart failure with symptoms or moderate to severe heart failure should not use Rosiglitazone.