Sorafenib tosylate
Sorafenib tosylate
- CAS:
- 475207-59-1
- MF:
- C21H16ClF3N4O3.C7H8O3S
- MW:
- 637.03
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Properties
- Melting point:
- 229-232°C
- storage temp.
- 2-8°C(protect from light)
- solubility
- Soluble in DMSO (up to 200 mg/ml) or in Ethanol (up to 3 mg/ml).
- form
- solid
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
- InChIKey
- IVDHYUQIDRJSTI-UHFFFAOYSA-N
- SMILES
- S(C1C=CC(C)=CC=1)(O)(=O)=O.O(C1C=CC(NC(=O)NC2C=CC(Cl)=C(C(F)(F)F)C=2)=CC=1)C1=CC=NC(C(=O)NC)=C1
Safety Information
- Symbol(GHS)
GHS08,GHS09
- Signal word
- Danger
- Hazard statements
- H360FD-H362-H372-H410
- Precautionary statements
- P201-P202-P260-P263-P273-P308+P313
- Risk Statements
- 36/37/38
- Safety Statements
- 28-26
- HS Code
- 29159000
Use
In a stage three randomized clinical study of American and European treatments for advanced kidney cancer, 903 cases advanced kidney patients who had experienced one unsuccessful systematic treatment (biological immunity or chemotherapy) were randomly split into two groups. One group received sorafenib tosylate, while the other received a placebo. Mid-term analysis found already 222 deaths and the objective efficacy of the two groups to be 10% and 2%, while 74% and 53% of patients had stabilized conditions. The sorafenib tosylate groups survival period was longer than that of the placebo group, with the risk ratio as 0.72. However, this different does not have statistical significance, as this is only a mid-term analysis, and final analysis after treatment will yield the correct survival period comparison. 602 advanced liver cancer patients selected from the USA, Europe, Australia, and other countries and areas, who did not receive systematic treatment, were included in a study. Results showed that compared to the placebo, taking sorafenib tosylate could extend their total survival period of patients with late stage or primary liver cancer by about 44% and their extend disease progression period by about 73%.
40 India supplier list of "Sorafenib tosylate"
- Product Name:Sorafenib tosylate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Hyderabad,INDIA
- Product Name:Sorafenib tosylate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Mumbai,INDIA
- Product Name:Sorafenib tosylate
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Karnataka,INDIA
- Product Name:Sorafenib tosylate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA
- Product Name:Sorafenib tosylate
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Haryana,INDIA
- Product Name:Sorafenib tosylate
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Sorafenib tosylate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Sorafenib tosylate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Sorafenib tosylate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Sorafenib tosylate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Haryana,INDIA