Stavudine manufacturers and suppliers in india

Stavudine

Properties

Melting point:: 159-160°C

alpha: D25 -39.4° (c = 0.701 in water); D20 -46.1° (c = 0.7 in water)

Density: 1.374±0.06 g/cm3(Predicted)

refractive index: -46 ° (C=0.69, H2O)

storage temp.: -20°C

solubility: Soluble in water, sparingly soluble in ethanol (96 per cent), slightly soluble in methylene chloride. It shows polymorphism (5.9).

form: Solid

pka: 9.47±0.10(Predicted)

color: White

Water Solubility: 5-10 g/100 mL at 21 ºC

BCS Class: 1,3

Stability:: Stable. Combustible. Incompatible with strong oxidizing agents.

InChIKey: XNKLLVCARDGLGL-JGVFFNPUSA-N

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H341

Precautionary statements: P201-P202-P280-P308+P313-P405-P501

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-36

WGK Germany: 2

RTECS: XP2075000

HS Code: 29349990

Toxicity: LD50 oral in rat: 4gm/kg

Use

Stavudine, 2'3'-didehydro-2'-deoxythymidine (D4T, Zerit), isan unsaturated pyrimidine nucleoside that is related to thymidine.The drug inhibits the replication of HIV by a mechanismsimilar to that of its close congener, AZT.Stavudine is bioactivatedby cellular enzymes to a triphosphate.Stavudine is available as capsules for oral administration.The drug is acid stable and well absorbed (about 90%) followingoral administration. Stavudine has a short half-life(1–2 hours) in plasma and is excreted largely unchanged(85%–90%) in the urine.As with ddC, the primary doselimitingeffect is peripheral neuropathy. Stavudine isrecommended for the treatment of adults with advancedHIV infection who are intolerant of other approved therapiesor who have experienced clinical or immunological deteriorationwhile receiving these therapies.