Sulfapyridine manufacturers and suppliers in india

Sulfapyridine

Properties

Melting point:: 191-193°C

Boiling point:: 473.5±51.0 °C(Predicted)

Density: 1.3220 (rough estimate)

refractive index: 1.6740 (estimate)

storage temp.: Keep in dark place,Sealed in dry,Room Temperature

solubility: DMSO (Slightly), Methanol (Slightly)

pka: pKa 8.48(H2O t = 25 I = 0.05) (Uncertain)

form: Solid

color: White to Off-White

Water Solubility: <0.1 g/100 mL at 22 ºC

Merck: 14,8938

BRN: 222065

Stability:: Stable. Combustible. Protect from light. Incompatible with strong oxidizing agents.

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H361fd

Precautionary statements: P201-P202-P280-P308+P313-P405-P501

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 22-24/25-36-26

WGK Germany: 2

RTECS: DA9625000

HazardClass: IRRITANT

HS Code: 29350010

Toxicity: LD50 orally in mice: 7.5 mg/g (Wien)

Use

Sulfapyridine’s plasma half-life is 9 hours.This compound is a white, crystalline, odorless, and tastelesssubstance. It is stable in air but slowly darkens on exposureto light. It is soluble in water (1:3,500), in alcohol(1:440), and in acetone (1:65) at 25°C. It is freely soluble indilute mineral acids and aqueous solutions of sodium andpotassium hydroxide. The pKa is 8.4. Its outstanding effectin curing pneumonia was first recognized by Whitby; however,because of its relatively high toxicity, it has been supplantedlargely by sulfadiazine and sulfamerazine. Severalcases of kidney damage have resulted from acetylsulfapyridinecrystals deposited in the kidneys. It also causes severenausea in most patients. Because of its toxicity, it is usedonly for dermatitis herpetiformis.Sulfapyridine was the first drug to have an outstandingcurative action on pneumonia. It gave impetus to the studyof the whole class of N1 heterocyclically substituted derivativesof sulfanilamide.