Trimetrexate glucuronate manufacturers and suppliers in india

Trimetrexate glucuronate

CAS:: 82952-64-5

MF:: C25H33N5O10

MW:: 563.56

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Properties

storage temp.: Store at -20°C

form: Solid

color: Off-white to light yellow

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H361

Precautionary statements: P201-P202-P281-P308+P313-P405-P501

Use

Trimetrexate glucuronate is a nonclassical antifolate introduced in the U.S.A. and Canada as second-line therapy for the treatment of Pneumocystis carinii pneumonia (PCP) and toxoplasmosis in AIDS patients who are refractory or intolerant to co-trimoxazole therapy. Trimetrexate glucuronate is reportedly to be in clinical trials for the treatment of several types of cancer including colorectal, gastric, pancreas, prostate, bladder, lung, breast, head, and neck cancers. It is also in early clinical trials for topical use in treating psoriasis and as an oral drug to treat rheumatoid arthritis. The mechanism of action of trimetrexate glucuronate is via inhibition of the enzyme dihydrofolate reductase which mediates the reduction of dihydrofolate to tetrahydrofolic acid and results in disruption of DNA, RNA and protein synthesis, with consequent cell death. Due to its toxicity to bone marrow and the GI tract, trimetrexate glucuronate must be concurrently administered with leucovorin as a rescue agent.