Trimetrexate
Trimetrexate
- CAS:
- 52128-35-5
- MF:
- C19H23N5O3
- MW:
- 369.42
Suppliers by country/region
Company Type
Properties
- Melting point:
- 215-217 °C
- Boiling point:
- 647.0±65.0 °C(Predicted)
- Density
- 1.305±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO : ≥ 61.5 mg/mL (166.48 mM)
- form
- Solid
- pka
- 8.09±0.30(Predicted)
- color
- Light yellow to green yellow
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Use
The drug is available as a lyophilized powder in 5- or 30-mgvials for IV use. The drug is used to treat colorectal cancer,head and neck cancer as well as NSCLC. The mechanism ofaction of trimetrexate involves folate antagonism and inhibitionof thymidylate synthesis. Trimetrexate does not formintracellular polyglutamate adducts as does methotrexateand other related compounds. Resistance can occur by increasedexpression of the target enzyme, decreased bindingaffinity for the target enzyme, or decreased intracellulardrug transport. Trimetrexate is administered only by the IVroute and distributed throughout the body with extensivebinding to plasma proteins. The major catabolic pathwaysinvolve O-demethylation followed by glucuronide conjugation.The drug interaction and toxicity profiles are similar tothose for methotrexate.
0 India supplier list of "Trimetrexate"
- Product Name:Trimetrexate
- Products Intro:Purity: 99.0% | Package: 100g;1kg;5kg;25kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Trimetrexate；CI-898
- Products Intro:Package: 1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；5 mg；50 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
- Product Name:Trimetrexate
- Products Intro:Purity: 0.99 | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: API(Active Pharmaceutical Ingredient),Lab Fine Chemical,Phytochemistry,Cosmetic Raw Materials
- Product Name:Trimetrexate
- Products Intro:Purity: 99% | Package: 50mg, 5mg, 10mg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Trimetrexate
- Products Intro:Purity: 0.97 | Package: mgs,gs,kgs | CustNote: A913386
- Company Type: Reagent
- Country/Region: CHINA
-
10 mg$320.0050 mg$1120.00
- Product Name:Trimetrexate
- Products Intro:Brand：dcchemicals | Product Number：DC23932 | Purity：>98%
- Company Type: Trader
- Country/Region: UNITED STATES
-
5mg$264.0010mg$480.0050mg$1680.00
- Product Name:Trimetrexate
- Products Intro:Brand：ChemScene | Product Number：CS-4063 | Purity：99.45%
- Company Type: Trader
- Country/Region: UNITED STATES
-
1mg$178.00
- Products Intro:Brand:1pchem | Product Number:1P00DBQ1 | Purity:98+%
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:Trimetrexate
- Products Intro:Brand：Chemenu | Product Number：CM143197 | Purity：98%
- Company Type: Trader
- Country/Region: UNITED STATES
-
10mg$280.0050mg$980.005mg$154.00
- Product Name:Trimetrexate
- Products Intro:Brand：Crysdot | Product Number：CD31001643 | Purity：98+%
- Company Type: Trader
- Country/Region: UNITED STATES