2’-O-Methyl-rA(N-Bz)phosphoramidite manufacturers
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| | 2’-O-Methyl-rA(N-Bz)phosphoramidite Basic information |
| Product Name: | 2’-O-Methyl-rA(N-Bz)phosphoramidite | | Synonyms: | 2’-O-Methyl-rA(N-Bz)phosphoramidite;N-blocked-5'-O-DMT-2'-O-Me CED adenosine phosphoramidite;5'-O-DMT-2'-O-Me-rA(N-Bz)-3'-CEDPA;N-Benzoyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methyladenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite;2'-OMe-Bz-A Phosphoramidite;Ac-dA Phosphoramidite;5'-O-DMT-2'-O-Me-A(bz) phosphoramidite;2'OMe-A CE PhosphoraMidite | | CAS: | 110782-31-5 | | MF: | C48H54N7O8P | | MW: | 887.96 | | EINECS: | 200-100-5 | | Product Categories: | Amidite | | Mol File: | 110782-31-5.mol |  |
| | 2’-O-Methyl-rA(N-Bz)phosphoramidite Chemical Properties |
| Melting point | 93-95°C | | storage temp. | Sealed in dry,2-8°C | | solubility | Acetonitrile (Sparingly), DMSO (Slightly), Methanol (Slightly) | | form | powder | | pka | 7.87±0.43(Predicted) | | color | white to off-white | | InChIKey | AZCGOTUYEPXHMJ-DCATYJMPNA-N |
| WGK Germany | 3 | | HS Code | 29349990 |
| | 2’-O-Methyl-rA(N-Bz)phosphoramidite Usage And Synthesis |
| Chemical Properties | White or off-white power | | Uses | (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a nucleotide used in the synthesis of native-like crosslinked duplex RNA. | | General Description |
Proligo′s 2′O-Methyl RNA monomers are compatible with fast deprotectionschemes that are based on the application of aliphatic amines, such asmethylamine. The adenosine and guanosine monomers are protected bythe standard benzoyl (bz) and isobutyryl (ib) groups.2′O-Methyl RNA is a nucleic acid analog that is characterized by theexceptional hybridization properties that it imparts with complimentary DNA or RNA, as well as increased stability against enzymatic degradationcompared to natural nucleic acids.The unique combination of properties of 2′O-Methyl RNA had foundwidespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules
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| | 2’-O-Methyl-rA(N-Bz)phosphoramidite Preparation Products And Raw materials |
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