Доксепин химические свойства, назначение, производство
Использование
Used clinically to treat anxiety and depression. Antidepressant
Определение
ChEBI: A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
Всемирная организация здравоохранения(ВОЗ)
Doxepin, a tricyclic antidepressant was introduced in 1964 for the
management of endogenous depression. Much of the adverse effects are caused
by its antimuscarinic actions. These include dry mouth, cardiac arrhythmias,
central nervous system disturbances, blood disorders and risk of suicide. The risk
of suicide and dangers related to overdosage led the Norwegian Medicines Control
Authority to put the higher strength formulation under prescribing restriction in
1992. The risk of death following overdosage is apparently higher for products
containing tricyclic compounds as compared with nontricyclic products.
Биологическая активность
Highly potent H 1 histamine receptor antagonist (K d = 310 pM) and tricyclic antidepressant. Also binds to the H 4 histamine receptor (pK i = 6.79).
Контактные аллергены
This benzoxepin tricylcic drug has antidepressant, anticholinergic,
antiitching, and antihistamine properties.
After oral use, it has been developed as a topical antiitching
agent. Allergic contact dermatitis is not infrequent.
Доксепин препаратная продукция и сырье
сырьё
препарат