Dacomitinib (PF299804)
Dacomitinib (PF299804)
- CAS:
- 1110813-31-4
- MF:
- C24H25ClFN5O2
- MW:
- 469.94
Suppliers by country/region
Company Type
Properties
- Melting point:
- 184-187°C
- Boiling point:
- 665.7±55.0 °C(Predicted)
- Density
- 1.344
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- White solid.
- pka
- 12.05±0.43(Predicted)
- color
- White to Pale Yellow
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P280-P305+P351+P338
- HS Code
- 29335990
Use
Dacomitibib (Dacomitinib, PF299804) is an effective and irreversible pan-ErbB inhibitor that is most effective in EGFR, with an IC50 of 6 nM. It is also highly effective in NSCLCs that carries EGFR or ERBB2 mutants (against Gefitinib) and EGFR T790M mutant. Phase 2. Dacomitinib is taken orally once-daily. It is an irreversible inhibitor of HER-1 (EGFR), HER-2 and HER-4 tyrosine kinases. Dacomitinib targets multiple receptors of the HER pathway, whereas currently marketed HER-1 (EGFR) inhibitors for non-small cell lung cancer (NSCLC) target only one receptor in this pathway,developed by Pfizer.
2 India supplier list of "Dacomitinib (PF299804)"
- Product Name:Dacomitinib
- Products Intro:Purity: 99% | Package: 1kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Kerela,INDIA
- Product Name:Dacomitinib
- Products Intro:Brand:pharmaffiliates | Product Number:PA042190000
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:Dacomitinib
- Products Intro:Brand:ajchemicals | Product Number:JDH-27980 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Dacomitinib
- Products Intro:Brand:tcichemicals | Product Number:D5450
- Company Type: Reagent
- Country/Region: New Delhi,INDIA
- Product Name:DacomitinibD5
- Products Intro:Brand:clearsynth | Product Number:CS-O-13264
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:Dacomitinibd5
- Products Intro:Brand:synzeal | Product Number:112805036
- Company Type: Trader
- Country/Region: Gujarat,INDIA
- Product Name:Dacomitinib (PF299804)
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:Dacomitinib
- Products Intro:Purity: 0.98 | Package: 1kg,10kg, 25kg per bag or drum
- Company Type: Manufacturer
- Country/Region: CHINA
- Main Products: Vilanterol intermediates,Bilastine intermediates,Glycopyrrolate Bromide intermediates,Piperidine intermediates,Pyridine intermediates
- Product Name:Dacomitinib
- Products Intro:Purity: 0.99 | Package: 1G；100G;1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1,4-Naphthalenedicarboxylic acid,Pamoic acid,Enfumafungin,6-bromonaphthalen-2-amine,Fusidic acid
- Product Name:Dacomitinib (PF299804)
- Products Intro:Purity: 0.99|Package: 1kg;0.00;USD
- Company Type: Manufacturer
- Country/Region: CHINA
- Main Products: lead acetate,Lead oxide,PMK ethyl glycidate,BMK Glycidic Acid,Diethyl(phenylacetyl)malonate
$0.00/ 1kg