Dexpanthenol manufacturers and suppliers in india

Dexpanthenol

Properties

Melting point:: 64～69℃

Boiling point:: 118-120 °C (2.7 mmHg)

alpha: 30.5 º (c=5, H2O on anh. sub)

Density: 1.20 g/mL at 20 °C (lit.)

vapor pressure: 0Pa at 25℃

refractive index: 1.495-1.502

Flash point:: 118-120°C/0.02m

storage temp.: 2-8°C

solubility: DMSO (Sparingly), Methanol (Slightly), Water (Sparingly)

pka: 13.03±0.20(Predicted)

form: Viscous Liquid or Semi Solid

color: Clear colorless to slightly yellow

PH: pH (100g/l,25℃) : 8.5～10.5

optical activity: [α]20/D +30±1°, c = 5% in H2O

Water Solubility: soluble

Sensitive: Hygroscopic

Merck: 14,2947

BRN: 1724947

InChIKey: SNPLKNRPJHDVJA-ZETCQYMHSA-N

LogP: -1.06 at 22℃

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H332-H335

Precautionary statements: P261-P280-P305+P351+P338

Hazard Codes: Xn

Risk Statements: 36/37/38-48-41-37/38-20/21/22

Safety Statements: 23-24/25-45-36/37/39-26-22

WGK Germany: 1

RTECS: ES4316000

F: 3-10

TSCA: Yes

HS Code: 29241990

Toxicity: LD50 oral in mouse: 15gm/kg

Use

Dexpanthenol belongs to a derivative of pantothenic acid (vitamin B5). It can penetrate the skin and mucous membrane to be quickly oxidized to pantothenic acid. The later one is extremely hygroscopic and binds water effectively. Therefore, Dexpanthenol can be used as a moisturizer. It is added to pharmaceutical and cosmetic products to relieve itching and improve wound healing. In ointments, it can be used for the treatment of sunburns, mild burns, minor skin injuries and disorders. It is also immediately applied after major abdominal surgery to minimize the possibility of paralytic ileus. In addition, it can also be supplemented into the commercial shampoos and hair conditioners to lubricate the hair shaft and give the hair a shiny appearance. The exact mechanism of action of Dexpanthenol is still unclear, perhaps through its enhancing effect on acetylcholine.