Felypressin manufacturers and suppliers in india

Felypressin

Properties

Melting point:: >197oC (dec.)

Boiling point:: 1571.3±65.0 °C(Predicted)

Density: 1.288±0.06 g/cm3(Predicted)

storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility: Freely soluble in water, practically insoluble in acetone and ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.

form: Solid

pka: 12.82±0.70(Predicted)

color: White

Sequence: H-[Cys-Phe-Phe-Gln-Asn-Cys]-Pro-Lys-Gly-NH2，(Disulfide bridge: Cys-Cys)

Safety Information

WGK Germany: 3

Use

Felypressin, 2-L-phenylalanine-8-L-lysinevasopressin, has relatively low antidiuretic activity and littleoxytocic activity. It has considerable pressor (i.e., vasoconstrictor)activity, which differs from that of epinephrine (i.e.,following capillary constriction in the intestine it lowers thepressure in the vena portae, whereas epinephrine raises theportal pressure). Felypressin also causes increased renalblood flow in the cat, whereas epinephrine brings about afall in renal blood flow. Felypressin is five times more effectiveas a vasopressor than is lysine vasopressin and is recommendedin surgery to minimize blood flow, especially inobstetrics and gynecology.