Halothane
Halothane
- CAS:
- 151-67-7
- MF:
- C2HBrClF3
- MW:
- 197.38
Suppliers by country/region
Properties
- Melting point:
- -115.75°C
- Boiling point:
- 50.2 °C(lit.)
- Density
- 1.872 g/mL at 25 °C(lit.)
- vapor pressure
- 4.5 psi ( 20 °C)
- refractive index
- n
20/D 1.369(lit.)
- Flash point:
- 49-50°C
- storage temp.
- 2-8°C
- solubility
- Slightly soluble in water, miscible with anhydrous ethanol and with trichloroethylene.
- form
- Colorless liquid
- color
- Colorless to light yellow
- Water Solubility
- Soluble in water (8 mg/ml).
- Sensitive
- Light Sensitive
- Merck
- 14,4603
- BRN
- 1736947
- Exposure limits
- TLV-TWA 50 ppm (～400 mg/m3) (ACGIH).
Safety Information
- Symbol(GHS)
GHS05,GHS07,GHS08
- Signal word
- Danger
- Hazard statements
- H315-H318-H335-H360
- Precautionary statements
- P201-P280-P305+P351+P338+P310-P308+P313
- Hazard Codes
- T,Xi,Xn
- Risk Statements
- 61-37/38-41-40-20
- Safety Statements
- 53-23-26-36/37-45-36
- RIDADR
- UN 3334
- OEL
- Ceiling: 2 ppm (16.2 mg/m3) [60-minute] [*Note: REL for exposure to waste anesthetic gas.]
- WGK Germany
- 3
- RTECS
- KH6550000
- F
- 8-19
- Hazard Note
- Irritant
- HS Code
- 2937990000
- Toxicity
- LD50 oral in rat: 5680mg/kg
Use
Halothane is a nonflammable, nonpungent, volatile, liquid,halogenated (F, Cl, and Br) ethane (bp＝50°C), introducedin 1956. Halothane may increase heart rate, cause cardiacarrhythmias, increase cerebral blood flow, and increase intracranialpressure.It can undergo spontaneous oxidationwhen exposed to ultraviolet light to yield HCl, HBr, Cl ,Br- , and phosgene (COCl2). To prevent oxidation it ispackaged in amber bottles with a low concentration of thymol(0.01%) as a stabilizer. The drug has a high potency(MAC＝0.75%), a blood:gas partition coefficient of 2.4,and high adipose solubility. Halothane undergoes both reductiveand oxidative processes with up to 20% of the doseundergoing metabolism .The trifluoroacetylchloride metabolite is electrophilic and can form covalentbonds with proteins leading to immune responses andhalothane hepatitis upon subsequent halothane exposure.Halothane hepatitis is rare with 1 case reported for every6,000 to 35,000 patients exposed.
8 India supplier list of "Halothane"
- Product Name:Halothane
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Halothane
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Halothane
- Company Type: Reagent
- Country/Region: Ahmedabad,INDIA
- Product Name:Halothane
- Company Type: Reagent
- Country/Region: Uttar Pradesh,INDIA
- Product Name:Halothane
- Company Type: Reagent
- Country/Region: Hyderabad,INDIA
- Product Name:Halothane
- Company Type: Reagent
- Country/Region: Delhi,INDIA
- Product Name:Halothane
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Halothane
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:Halothane(1303501)
- Products Intro:Brand:pharmaffiliates | Product Number:PAUSP1303501
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:Halothane
- Products Intro:Brand:clearsynth | Product Number:CS-T-78850
- Company Type: Trader
- Country/Region: Hyderabad,INDIA