Lonidamine
Lonidamine
- CAS:
- 50264-69-2
- MF:
- C15H10Cl2N2O2
- MW:
- 321.16
Suppliers by country/region
Company Type
Properties
- Melting point:
- 207-209°C
- Boiling point:
- 537.9±45.0 °C(Predicted)
- Density
- 1.4835 (rough estimate)
- refractive index
- 1.6070 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Soluble in DMSO (up to 25 mg/ml).
- form
- solid
- pka
- 3.00±0.10(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
- InChIKey
- WDRYRZXSPDWGEB-UHFFFAOYSA-N
Safety Information
- Symbol(GHS)
GHS07,GHS08
- Signal word
- Danger
- Hazard statements
- H302-H351-H360
- Precautionary statements
- P201-P301+P312+P330-P308+P313
- Hazard Codes
- T
- Risk Statements
- 60-22-40
- Safety Statements
- 53-22-36/37/39-45
- WGK Germany
- 3
- RTECS
- NK7886000
- HS Code
- 29339900
- Toxicity
- LD50 in mice, rats (mg/kg): 900, 1700 orally; 435, 525 i.p. (Heywood)
Use
Lonidamine is a derivative of indazole-3-carboxylic acid. It is a kind of orally administrated small molecule, which can inhibit the glycolysis process through inactivating the hexokinase (the first step in glycolysis). It has been shown that cancer cell primarily generates energy through glycolysis process. Therefore, Lonidamine has been used for the treatment of several kinds of cancers. One special property of Lonidamine is that it seems to enhance aerobic glycolysis in normal cells, but inhibit glycolysis only in cancer cells. In addition, there are also evidences that Lonidamine may increase the occurrence of apoptosis. It has also been shown that Lonidamine is effective in the treatment of benigh prostatic hyperplasia (BPH).
2 India supplier list of "Lonidamine"
- Product Name:Lonidamine
- Products Intro:Brand:sigma aldrich | Product Number:L4900 | Purity:mitochondrialhexokinaseinhibitor
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Lonidamine
- Products Intro:Purity: 99%|Package: 1KG;9.10;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: acetic acid,Ethyl oleate,Hypophosphorous acid,tetramisole,OPP
$9.10/ 1KG
- Product Name:Lonidamine
- Products Intro:Purity: 98% | Package: 1KG;1USD
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
$1.00/ 1KG