Mefenamic acid
Mefenamic acid
- CAS:
- 61-68-7
- MF:
- C15H15NO2
- MW:
- 241.29
Suppliers by country/region
- India(142)
- China(209)
- United States(51)
- Canada(5)
- United Kingdom(19)
- Europe(2)
- Slovakia(1)
- France(5)
- Germany(10)
- Ukraine(1)
- Switzerland(2)
- Japan(2)
- Singapore(1)
- Venezuela(1)
- Spain(3)
- Poland(1)
- Italy(1)
- Brazil(3)
- Indonesia(3)
- Belgium(2)
- South Korea(4)
- Czech Republic(1)
- Philippines(1)
- Malaysia(1)
- United Arab Emirates(1)
- Bangladesh(1)
- Austria(1)
Company Type
Properties
- Melting point:
- 230 °C
- Boiling point:
- 384.06°C (rough estimate)
- Density
- 1.0944 (rough estimate)
- refractive index
- 1.5200 (estimate)
- storage temp.
- 2-8°C
- solubility
- Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides
- form
- Solid
- pka
- 4.2(at 25℃)
- color
- White to Pale Yellow
- Water Solubility
- It is soluble in acetone, chloroform, dichloromethane, methanol. Insoluble in water.
- Merck
- 14,5798
- InChIKey
- HYYBABOKPJLUIN-UHFFFAOYSA-N
- LogP
- 5.120
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P301+P312+P330
- Hazard Codes
- Xn
- Risk Statements
- 22-40-20/21/22
- Safety Statements
- 22-36
- WGK Germany
- 3
- RTECS
- CB4550000
- HS Code
- 28142000
- Toxicity
- LD50 orally in mice, rats: 630, 790 mg/kg (Jahn, Adrian)
Use
Mefenamic acid (Ponstel, Ponstan) is one of the oldestNSAIDs, introduced into the market in 1967 for mild tomoderate pain and for primary dysmenorrhea. It is rapidly absorbed with peak plasma levels occurring 2 to 4 hoursafter oral administration. It undergoes hepatic benzylic hydroxylationof its 3'methyl group regioselectively into twoinactive metabolites, 3'-hydroxymethylmefenamic acid andthe 3'carboxylate metabolite (via further oxidation of thebenzylic alcohol group). The parent drugs and these metabolitesare conjugated with glucuronic acid and excreted primarilyin the urine. Thus, although patients with knownliver deficiency may be given lower doses, it is contraindicatedin patients with preexisting renal dysfunction.Common side effects associated with its use include diarrhea,drowsiness, and headache. The possibility of blood disordershas also prompted limitation of its administration to 7days. It is not recommended for children or during pregnancy.
142 India supplier list of "Mefenamic acid "
- Product Name:Mefenamic acid
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Mefenamic acid
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Mefenamic acid
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Mefenamic acid
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Uttar Pradesh,INDIA
- Product Name:Mefenamic acid
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Bangalore,INDIA
- Product Name:Mefenamic acid
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Trader
- Country/Region: NaviMumbai,INDIA
- Product Name:Mefenamic acid
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:MEFENAMIC ACID
- Products Intro:Purity: 95-99 % | Package: 1-5 gm, the rest upon order
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Mefenamic acid
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA
- Product Name:Mefenamic Acid
- Products Intro:Purity: 99% | Package: Kg to Mtons
- Company Type: Reagent
- Country/Region: Telangana,INDIA