methoxyflurane
methoxyflurane
- CAS:
- 76-38-0
- MF:
- C3H4Cl2F2O
- MW:
- 164.97
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Properties
- Melting point:
- -36°C
- Boiling point:
- 103 °C
- Density
- 1.4262
- refractive index
- 1.386
- Flash point:
- 37°C
- storage temp.
- -70°C
- solubility
- Chloroform (Sparingly)
- form
- liquid
- color
- Clear
- Water Solubility
- Miscible with alcohol, acetone, chloroform, ether, fixed oils and benzene. Immiscible with water.
- Merck
- 14,5994
- BRN
- 1737766
- Exposure limits
- No exposure limit is set. Based on comparison with related compounds, a TLV-TWA of 675 mg/m3 (100 ppm) is recommended.
- Stability:
- Stability
Safety Information
- Symbol(GHS)
GHS02,GHS07
- Signal word
- Warning
- Hazard statements
- H226-H319-H341
- Precautionary statements
- P210-P241-P308+P311
- Hazard Codes
- Xi
- Risk Statements
- 10
- Safety Statements
- 23-24/25
- RIDADR
- 3271
- OEL
- Ceiling: 2 ppm (13.5 mg/m3) [60-minute] [*Note: REL for exposure to waste anesthetic gas.]
- RTECS
- KN7820000
- Hazard Note
- Irritant
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 2909191800
- Toxicity
- One of the most potent of the inhalational anesthetics, having a very high blood-gas partition coefficient and low vapor pressure at room temperature. Methoxyflurane is metabolized to a great extent (about 50-70%) in the liver and, as a consequence, there may be release of high concentrations of fluoride, sufficient to exceed the threshold for renal damage. Its use for sustained anesthesia is limited because of this renal toxicity and was discontinued around 1980.
Use
Methoxyflurane is a volatile liquid (bp=105°C) with a highblood:gas partition coefficient and thus a slow induction andprolonged recovery. Approximately 75% of the drug undergoesmetabolism yielding dichloroacetate, difluoromethoxyacetate,oxalate, and fluoride ions. The intrarenal inorganicfluoride concentration, as a result of renal defluorination, maybe responsible for the nephrotoxicity seen with methoxyflurane.Both the concentration of F- generated and the durationfor which it remained elevated were factors in the developmentof methoxyflurane nephrotoxicity. Methoxyfluranewas removed from the U.S. market in 2000 because of saferalternatives. Both isoflurane and enflurane produce less fluorideion upon metabolism than methoxyflurane.
1 India supplier list of "methoxyflurane"
- Product Name:KAT8(2-467),GSTtaggedhuman
- Products Intro:Brand:sigma aldrich | Product Number:SRP5220 | Purity:recombinant,expressedinbaculovirusinfectedSf9cells,≥70%(SDS-PAGE),bufferedaqueou
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Mof
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:methoxyflurane
- Products Intro:Purity: 99% | Package: 100KG;10KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA