Mevastatin
Mevastatin
- CAS:
- 73573-88-3
- MF:
- C23H34O5
- MW:
- 390.51
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Properties
- Melting point:
- 151-153 °C
- alpha
- D22 +283° (c = 0.48 in acetone)
- Boiling point:
- 555.0±50.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- vapor pressure
- 0Pa at 25℃
- storage temp.
- 2-8°C
- solubility
- DMSO: 20 mg/mL
- pka
- 13.49±0.40(Predicted)
- form
- powder
- color
- white
- λmax
- 246nm(MeOH)(lit.)
- Merck
- 14,6164
- BRN
- 1269441
- InChIKey
- AJLFOPYRIVGYMJ-INTXDZFKSA-N
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Danger
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c
- Hazard Codes
- T+
- Risk Statements
- 26/27/28
- Safety Statements
- 22-24/25-45-36/37/39
- WGK Germany
- 3
- RTECS
- EK7907100
- F
- 1-8-10
- HS Code
- 29322090
Use
Mevastatin (compactin) is a diterpene produced by several species of the genera Penicillium and Monascus, first reported in 1976. Mevastatin, the prototype of the statin class, is a potent competitive inhibitor of HMG-CoA reductase, a regulatory enzyme for cholesterol biosynthesis. Mevastatin has also been shown to induce apoptosis by inhibiting post-translational prenylation of proteins such as Ras, increasing eNOS mRNA and protein levels by blocking the geranylgeranylation of Rho, and inhibiting myoblast fusion. It induces cell cycle arrest in late G1 phase and may induce bone morphogenic protein-2 (BMP-2).
3 India supplier list of "Mevastatin"
- Product Name:Mevastatin-CAS73573-88-3-Calbiochem
- Products Intro:Brand:sigma aldrich | Product Number:474700 | Purity:AnantibioticthatactsasapotentinhibitorofHMG-CoAreductase,thussuppressingRasfarne
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Mevastatin
- Products Intro:Brand:synzeal | Product Number:157637721
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Mevastatin
- Products Intro:Brand:pharmaffiliates | Product Number:PA1229010
- Company Type: Trader
- Country/Region: INDIA