Mevastatin | 73573-88-3

Mevastatin Properties

Melting point	151-153 °C
alpha	D22 +283° (c = 0.48 in acetone)
Boiling point	555.0±50.0 °C(Predicted)
Density	1.13±0.1 g/cm3(Predicted)
vapor pressure	0Pa at 25℃
storage temp.	2-8°C
solubility	DMSO: 20 mg/mL
pka	13.49±0.40(Predicted)
form	powder
color	white
λmax	246nm(MeOH)(lit.)
Merck	14,6164
BRN	1269441
InChIKey	AJLFOPYRIVGYMJ-INTXDZFKSA-N
CAS DataBase Reference	73573-88-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Danger
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c
Hazard Codes	T+
Risk Statements	26/27/28
Safety Statements	22-24/25-45-36/37/39
WGK Germany	3
RTECS	EK7907100
F	1-8-10
HS Code	29322090

Mevastatin price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	M2537	Mevastatin ≥98% (HPLC), powder or crystals	73573-88-3	5MG	₹14938.5	2022-06-14	Buy
Sigma-Aldrich	474700	Mevastatin - CAS 73573-88-3 - Calbiochem An antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppressing Ras farnesylation.	73573-88-3	50MG	₹15469.99	2022-06-14	Buy
Sigma-Aldrich(India)	474700	Mevastatin - CAS 73573-88-3 - Calbiochem An antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppressing Ras farnesylation.	73573-88-3	50MG	₹15469.99	2022-06-14	Buy
TCI Chemicals (India)	M2275	Mevastatin	73573-88-3	100MG	₹2800	2022-05-26	Buy
TCI Chemicals (India)	M2275	Mevastatin	73573-88-3	1G	₹11700	2022-05-26	Buy

Product number	Packaging	Price	Buy
M2537	5MG	₹14938.5	Buy
474700	50MG	₹15469.99	Buy
474700	50MG	₹15469.99	Buy
M2275	100MG	₹2800	Buy
M2275	1G	₹11700	Buy

Mevastatin Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Mevastatin (compactin) is a diterpene produced by several species of the genera Penicillium and Monascus, first reported in 1976. Mevastatin, the prtotype of the statin class, is a potent competitive inhibitor of HMG-CoA reductase, a regulatory enzyme for cholesterol biosynthesis. Mevastatin has also been shown to induce apoptosis by inhibiting post-translational prenylation of proteins such as Ras, increasing eNOS mRNA and protein levels by blocking the geranylgeranylation of Rho, and inhibiting myoblast fusion. It induces cell cycle arrest in late G1 phase and may induce bone morphogenic protein-2 (BMP-2).

Definition

ChEBI: A carboxylic ester that is pravastatin that is lacking the allylic hydroxy group and in which the lactone moiety has been hydrolysed to the corresponding delta-hydroxy-carboxylic acid. A hydroxymethylglutaryl-CoA reductase inhibitor (stati ) isolated from Penicillium citrinum and from Penicillium brevicompactum, its clinical use as a lipid-regulating drug ceased following reports of toxicity in animals.

General Description

Chemical structure: statin

Biological Activity

Inhibitor of HMG-CoA reductase; decreases cholesterol biosynthesis, in vitro and in vivo . Induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27.

Purification Methods

Purify compactin by recrystallisation from aqueous EtOH. UV (EtOH): max 230, 237 and 246nm (log 4.28, 4.30 and 4.11); IR (KBr): 3520, 1750 (lactone CO) and 1710 (CO ester) cm-1. [Clive et al. J Am Chem Soc 110 6914 1988, Review: Rosen & Heathcock Tetrahedron 42 4909 1986, IR, NMR, MS: Brown et al. J Chem Soc Perkin Trans 1 1165 1976.] It is a potent inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase), an enzyme in cholesterol biosynthesis, and lowers cholesterol levels [Brown et al. J Biol Chem 253 1121 1978, Nakamura & Ableles Biochemistry 24 1364 1985, Beilstein 18/3 V 145].

Mevastatin Preparation Products And Raw materials

Raw materials

Preparation Products

Mevastatin Suppliers

Global( 342)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
OCEAN TRADING CORPORATION	+91(22) 24921669	New Delhi, India	6211	58	Inquiry
BIOCON LTD	+91 80 2808 2808	New Delhi, India	39	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Alfa Aesar	1 800 209 7001	Maharashtra, India	6913	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Triveni chemicals	08048762458	New Delhi, India	6093	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	China	12459	58	Inquiry

Supplier	Advantage
OCEAN TRADING CORPORATION	58
BIOCON LTD	58
TCI Chemicals (India) Pvt. Ltd.	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Alfa Aesar	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Triveni chemicals	58
SynZeal Research Pvt Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58

Mevastatin Spectrum

Mevastatin(73573-88-3)¹HNMR

73573-88-3(Mevastatin)Related Search:

METSULFURON METHYL Methyl acrylate Tribenuron methyl Rosuvastatin calcium Methylparaben

Pravastatin Methanol Methyl salicylate Fluvastatin Simvastatin

Atorvastatin Basic Violet 1 Butyric Acid Atorvastatin calcium Kresoxim-methyl

Methyl Lovastatin Pravastatin Lactone

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Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)- ,8-beta(2s*,4s*),8a-beta))- antibioticml236b butanoicacid,2-methyl-,1,2,3,7,8,8a-hexahydro-7-methyl-8-(2-(tetrahydro-4-hy compactin(penicillium) (S)-2-Methylbutyric acid [(1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]naphthalen-1-yl] ester 2-Methyl-butanoic acid [1S-[1-α(R*),7-β,8-β(2S*,4S*),8a-β]]-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester Mevastatin, >=97% (2S)-2-methylbutyric acid [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-keto-tetrahydropyran-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] ester [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate (2S)-2-Methyl-(1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenylbutanoate Mevastatin,Compactin, ML-236B Mevastatin API Lovastatin EP IMpurity A MEVASTATIN(SH) CoMpactin, ML 236B, SIPI 8915 (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-Methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-Methylbutanoate droxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenylester,(1s-(1-alpha(r*),7-beta ml236blactone 6-DEMETHYLVEVINOLIN 2-methyl-butanoic acid [1s-[1-alpha(r*),7-beta,8-beta(2s*,4s*),8a-beta]]-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl]-1-naphthalenyl ester (2S)-2-METHYL-(1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HYDROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENYL BUTANOATE MEVASTATIN MEVASTIN CS-500 Merastatin MEVASTATIN 95+% Compactin, 6-Demethylvevinolin, CS-500, ML-236 B MEVASTATIN(RG) COMPACTIN (MEVASTATIN) [(1S,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (2S)- (1S,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthyl (S)-2-methylbutyrate (2S)-2-Methylbutyric acid [(1S)-1,2,3,7,8,8aα-hexahydro-7α-methyl-8α-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]naphthalen-1β-yl] ester Compactin, ML-236B Mevastatin (ML236B) Pravastatin Deshydroxy Impurity Mevastatin Solution, 100ppm Mevastatin, 98%, a potent HMG-CoA reductase inhibitor Mevastatin Mevastatin Lovastatin Impurity 1(Lovastatin EP Impurity A) Mevastatin, ≥96%(HPLC) Mevastatin - CAS 73573-88-3 - Calbiochem Lovastatin EP Impurity A (Mevastatin) Mevastatin> sjxqpil80ozl2eonzya8tqee.png Mevastatin USP/EP/BP MEVASTATIN/ COMPACTIN 97% UP Lovastatin EP Impurity A (Pravastatin Deshydroxy Impurity/ Mevastatin/ Compactin) Pravastatin Deshydroxy Impurity (Lovastatin EP Impurity A/ Mevastatin/ Compactin) MevastatinQ: What is Mevastatin Q: What is the CAS Number of Mevastatin Q: What is the storage condition of Mevastatin Q: What are the applications of Mevastatin ML-236B COMPACTIN Lovastatin Impurity A 73573-88-3 BioChemical Antibiotics G-M