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Pravastatin

Pravastatin Structure
CAS No.
81093-37-0
Chemical Name:
Pravastatin
Synonyms
MEVALOTIN;PRAVACHOL;ELISOR;KOPOSTAT;Pravatatin;PRAVASELECT;PRAVASTATIN;Pravastatin-D9;PRAVASTATIN(RG);EPTASTATIN SODIUM
CBNumber:
CB6317122
Molecular Formula:
C23H36O7
Molecular Weight:
424.53
MOL File:
81093-37-0.mol
MSDS File:
SDS
Modify Date:
2024/5/8 14:48:35
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Pravastatin Properties

Melting point 171.2-173 °C
Boiling point 634.5±55.0 °C(Predicted)
Density 1.21±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility H2O: 19 mg/mL
pka 4.31±0.10(Predicted)
form powder
color white
CAS DataBase Reference 81093-37-0(CAS DataBase Reference)
EPA Substance Registry System 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-.beta.,.delta.,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, (.beta.R,.delta,R,1S,2S,6S,8S,8aR)- (81093-37-0)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08,GHS09
Signal word  Danger
Hazard statements  H350-H360--H410
Precautionary statements  P273-P260-P314-P501
Hazard Codes  F,C
Risk Statements  11-34
Safety Statements  16-26-36/37/39-45
WGK Germany  2
RTECS  QJ7185000
NFPA 704
0
3 0

Pravastatin Chemical Properties,Uses,Production

Description

Pravastatin is the third HMG-CoA reductase inhibitor introduced for the treatment of atherosclerosis. Compared with lovastatin and simvastatin launched earlier, pravastatin is equipotent as an HMG-CoA reductase inhibitor in vitro, yet it is reported to be more tissue-selective.

Chemical Properties

Off-white Cryst

Uses

antiglaucoma,

General Description

Pravastatin, sodium 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoate (Pravachol), is the most rapid actingof the three HMG-CoA reductase inhibitor drugs, reachinga peak concentration in about 1 hour. The sodium salt of theβ-hydroxy acid is more hydrophilic than the lactone forms ofthe other two agents, which may explain this property. In addition,the open form of the lactone ring contributes to a morehydrophilic agent, which, in turn, results in less CNS penetration.This explains, in part, why pravastatin has fewer CNSside effects than the more lipophilic lactone ester of this classof agents. Absorption of pravastatin following oral administrationcan be inhibited by resins such as cholestyramine becauseof the presence of the carboxylic acid function on thedrug. The lactone forms of lovastatin and simvastatin are lessaffected by cholestyramine.

Pravastatin Preparation Products And Raw materials

Raw materials

Liquid Chromatography Sodium sulfate Trifluoroacetic acid Ethyl acetate Propiophenone
Sodium bicarbonate
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Preparation Products

Pravastatin Suppliers

Global( 158)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
OCEAN TRADING CORPORATION +91(22) 24921669 New Delhi, India 6211 58 Inquiry
Medilink Pharmachem +91 (79) 3007-0133 New Delhi, India 424 50 Inquiry
Triveni chemicals 08048762458 New Delhi, India 6093 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
First Continental Online Pharmacy 09910470260 Kolkata, India 2 58 Inquiry
Koshambh Multitred Private Limited 08048250245Ext 483 Vadodara, India 3 58 Inquiry
Vista Inc. 09177778907 Maharashtra, India 7 58 Inquiry
CONCORD BIOTECH LIMITED +91 79 68138700 New Delhi, India 11 58 Inquiry
Luna Chemical Industries Private Limited 08048372754Ext 585 Vadodara, India 22 58 Inquiry
Supplier Advantage
OCEAN TRADING CORPORATION 58
Medilink Pharmachem 50
Triveni chemicals 58
SynZeal Research Pvt Ltd 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
First Continental Online Pharmacy 58
Koshambh Multitred Private Limited 58
Vista Inc. 58
CONCORD BIOTECH LIMITED 58
Luna Chemical Industries Private Limited 58

81093-37-0(Pravastatin)Related Search:

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KOPOSTAT PRAVASTATIN PRAVASELECT ELISOR EPTASTATIN SODIUM (BETA R,DELTA R,1S,2S,6S,8S,8AR)-1,2,6,7,8,8A-HEXAHYDRO-BETA,DELTA,6-TRIHYDROXY-2-METHYL-8-[(2S)-2-METHYL-1-OXOBUTOXY]-1-NAPHTHALENEHEPTANOIC ACID MONOSODIUM SALT (BETAR, DELTAR,1S,2S,6S,8S,8AR)-1,2,6,7,8,8A-HEXAHYDRO-BETA, DELTA,6-TRIHYDROXY-2-METHYL-8[(2S)-2-METHYL-1-OXOBUTOXYL]-1-NAPHTHALENEHEPTANOIC ACID SODIUM (BETA-R,DELTA-R,1S,2S,6S,8S,8AR)-1,2,6,7,8,8A-HEXAHYDRO-BETA,DELTA,6-TRIHYDROXY-2-METHYL-8[(2S)-2-METHYL-1-OXOBUTOXYL]-1-NAPHTHALENEHEPTANOIC ACID NA [1s-[1a(bs,ds),2a,6b,8b(r),8aa]]-1,2,6,7,8,8a-hexahydro-b,d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid monosodium salt (+)-(3r,5r)-3,5-dihydroxy-7-[(1s,2s,6s,8s,8ar)-6-hydroxy-2-methyl-8-[(s)-2-methylbutyryloxy]-1,2,6,7,8,8a-hexahydro-1-naphthyl]-heptanoic acid 3BETA-HYDROXYCOMPACTIN, NA (3R,5R)-7-[(1S,2R,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxy-heptanoic acid PRAVASTATIN(RG) 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-b,d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, [1S-[1a(bS*,dS*),2a,6a,8b(R*),8aa]]- 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-b,d,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, (bR,dR,1S,2S,6S,8S,8aR)- (9CI) 3b-Hydroxycompactin PRAVASTATIN FREE BASE Pravatatin 3β-Hydroxycompactin Sodium salt sodium(+)-(3R，5R)-3，5-Dihydroxy-7-[(1S，2S，6S，8αR)-6-hydroxy-2-methyl-8-[(S)-2-methyl-hutyryloxy]1，2，6，7，8，8α-hexahydro-1-naphthyl]heptanoate (1S,βR,δR,8aβ)-1,2,6,7,8,8a-Hexahydro-β,δ,6β-trihydroxy-2β-methyl-8α-[(S)-2-methyl-1-oxobutoxy]-1β-naphthaleneheptanoic acid Pravastatin-D9 (3R,5R)-3,5-dihydroxy-7-((1S,2S,6S,8S,8aR)-6-hydroxy-2-Methyl-8-(((S)-2-Methylbutanoyl)oxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoic acid PRAVASTATIN (CS-514) (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S)-6-hydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, (βR,δR,1S,2S,6S,8S,8aR)- Pravastatin USP/EP/BP PravastatinQ: What is Pravastatin Q: What is the CAS Number of Pravastatin MEVALOTIN PRAVACHOL 81093-37-0 81131-76-6 C23H36O7 Biochemicals and Reagents BioChemical D to K Enzyme Inhibitors by Enzyme Enzyme Inhibitors Enzymes, Inhibitors, and Substrates Hydroxymethylglutaryl-CoA Reductase Selektine