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Atorvastatin

CAS No.: 134523-00-5

Chemical Name:: Atorvastatin

Synonyms: ATORVASTATIN CA;Atorvastatin (Subject to Patent free);ATORVASTATIN CALCIUM SALT;Atorvastatin acid;ATORVASTATIN DIPROTECTED;Atorvastatin CalciuM Tablets;(3r,5r)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-yl-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid;Cardyl;025-83371857;Atrovastitne

CBNumber:: CB4239912

Molecular Formula:: C33H35FN2O5

Molecular Weight:: 558.65

MOL File:: 134523-00-5.mol

MSDS File:: SDS

Modify Date:: 2024/8/2 18:12:07

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Atorvastatin Properties

Melting point	176-178°C
Boiling point	722.2±60.0 °C(Predicted)
Density	1.23±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 100 mg/mL (179.01 mM)
pka	pKa 4.46(H2O t=30 Iuncontrolled) (Uncertain)
form	Solid
color	White to light yellow
CAS DataBase Reference	134523-00-5(CAS DataBase Reference)
EPA Substance Registry System	1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, (?R,?R)- (134523-00-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS03,GHS07
Signal word	Warning
Hazard statements	H272-H315-H319-H335
Precautionary statements	P221-P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P370+P378r-P370+P380+P375-P380-P501c
Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	26-36
HS Code	35040000

Atorvastatin Chemical Properties,Uses,Production

Chemical Properties

white Crystalline powder

Uses

antihyperlipoproteimic;HMG-CoA reductase inhibition

General Description

Atorvastatin, [R-(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-lH-pyrrole-1-heptanoic acid(Lipitor), also possesses the heptanoic acid side chain,which is critical for inhibition of HMG-CoA reductase.Although the side chain is less lipophilic than the lactoneform, the high amount of lipophilic substitution causes this agent to have a slightly higher level of CNS penetration thanpravastatin, resulting in a slight increase in CNS side effects.Even so, its CNS profile is much lower than that of lovastatin.Atorvastatin is marketed as a combination therapywith amlodipine under the trade name Norvasc for managementof high cholesterol and high blood pressure.

Atorvastatin Preparation Products And Raw materials

Raw materials

Triethylborane Sodium borohydride 2,3-diaminonaphthalene (S)-(-)-2-ACETOXY-1,1,2-TRIPHENYLETHANOL Magnesium

n-Butyllithium

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Preparation Products

Atorvastatin Suppliers

Global( 283)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CHEMXTREE STANDARDS	+919872732255	Punjab, India	96	58	Inquiry
OPULENT PHARMA	+91-9106692785 +91-9106692785	Gujarat, India	479	58	Inquiry
Anant Pharmaceuticals Pvt Ltd	+91-8550986868 +91-9485998001	Haryana, India	461	58	Inquiry
Vadivarhe Speciality Chemicals Limited	+91-9028832204 +91-9028832204	Maharashtra, India	38	58	Inquiry
GLP Pharma Standards	+91 9866074638	Hyderabad, India	1644	58	Inquiry
Evans Fine Chem	+91-9821340302 +91-9821340302	Maharashtra, India	286	58	Inquiry
Shree HariKrishna Pharmaceuticals	+91-9925611910 +91-9925611910	Gujarat, India	16	58	Inquiry
Sainor Life Sciences Pvt Ltd	+919542990009	AndhraPradesh, India	13	58	Inquiry
Svak Life Sciences	+91-9963463333 +91-9705383777	Hyderabad, India	101	58	Inquiry
Dayaram Pharma Chem	+91-9601766800 +91-9601766800	Gujarat, India	61	58	Inquiry

Supplier	Advantage
CHEMXTREE STANDARDS	58
OPULENT PHARMA	58
Anant Pharmaceuticals Pvt Ltd	58
Vadivarhe Speciality Chemicals Limited	58
GLP Pharma Standards	58
Evans Fine Chem	58
Shree HariKrishna Pharmaceuticals	58
Sainor Life Sciences Pvt Ltd	58
Svak Life Sciences	58
Dayaram Pharma Chem	58

Atorvastatin Spectrum

Atorvastatin(134523-00-5)¹HNMR

134523-00-5(Atorvastatin)Related Search:

PHENYL VALERATE Simvastatin Pyrrolidine N-Vinyl-2-pyrrolidone Diphenyl ether

Polyvinylpyrrolidone Phenyl salicylate Propane N-Methyl-2-pyrrolidone ATORVASTATIN LACTONE,Atorvastatin d-Lactone

PHENYL RESIN ATORVASTATIN SODIUM O-HYDROXY ATORVASTATIN LACTONE Phenylacetic acid ATORVASTATIN CA,ATORVASTATIN CALCIUM,ATORVASTATIN CA,ATORVASTATIN CALCIUM SALT,Atorvastatin Calclum,ATORVASTATIN CALCIUM MM(CRM STANDARD)

Atorvastatin tert-Butyl Ester Atorvastatin Intermediate Ⅰ,Atorvastatin Intermediate 1 Atorvastatin Intermediate 2 ,Atorvastatin Intermediate Ⅱ

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Atorvastatin&Ats-5Ats-8Ats-9M4L1 Atrovastitne (bR,dR)-2-(p-Fluorophenyl)-β,δ-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoic acid 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, (βR,δR)- 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, [R-(R*,R*)]- Cardyl [R-(R^<*>^，R^<*>^)]-2-(4-Fluorophenyl)- β，δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylarnino)carbonyl]-1H．Pyrrole-1- heptanoic acid (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxy-enanthic acid (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbaMoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid 025-83371857 (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbaMoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid (3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydr (3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dih ATORVASTATIN (3R,5R)-2-(4-Fluorophenyl)-3,5-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid Atorvastatin free ACID Atorvastatin USP/EP/BP Atorvastatin DISCONTINUED See A791750 or A791730 Atorvastatin acid Atorvastatin CalciuM Tablets ATORVASTATIN DIPROTECTED Atorvastatin (Subject to Patent free) (3r,5r)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-yl-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid ATORVASTATIN CA ATORVASTATIN CALCIUM SALT Atorvastatin calcium salt Calcium (3R,5R)-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3- phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]- 3,5dihydroxyheptanoate (3R，5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3，5-dihydroxyheptanoic acid 134523-00-5 134523-03-0 C33H34FN2O53H2O C33H35FN2O5 C33H33CaFNO5