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Atorvastatin calcium

CAS No.: 134523-03-8

Chemical Name:: Atorvastatin calcium

Synonyms: Atorvastatin CalciuM Trihydrate;ATORVASTATIN CA;Atrovastatin calcium;ATORVASTATIN CALCIUM SALT;Atorvastatin Ca Hydrate;Atorvastatin Calcium RS;Atorvastatin Calcium Anhydrous;Atorvastatin calciuM salt trihydrate;[r-(r*, r*)]-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylaminocarbonyl)-1h-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid calcium salt;Tahor

CBNumber:: CB4260130

Molecular Formula:: C33H37CaFN2O5

Molecular Weight:: 600.74

MOL File:: 134523-03-8.mol

MSDS File:: SDS

Modify Date:: 2024/7/26 15:15:06

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Atorvastatin calcium Properties

Melting point	176-178°C
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO: ≥10mg/mL
form	white powder
color	White to Off-White
BCS Class	2
InChIKey	FQCKMBLVYCEXJB-MNSAWQCASA-L
CAS DataBase Reference	134523-03-8(CAS DataBase Reference)
EPA Substance Registry System	1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-.beta.,delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt (2:1),(.beta.R,.delta.R)- (134523-03-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08,GHS09
Signal word	Warning
Hazard statements	H411-H351-H361f-H372-H319
Precautionary statements	P201-P202-P281-P308+P313-P405-P501-P260-P264-P270-P314-P501-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes	Xn,T,F
Risk Statements	20/21/22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements	26-36-45-36/37-16-7
WGK Germany	3

Atorvastatin calcium Chemical Properties,Uses,Production

Description

Lipitor was launched in Canada, the Netherlands, the UK and the US as an orally-active hypocholesterolemic agent. It was the first pharmaceutical product ever to attain over one billion dollars in sales in its first year. It can be synthesized by a number of routes but the most efficient involves the Paal-Knorr reaction of an acetonide protected dihydroxy amino ester and a diaryl phenylacetamide diketone. Lipitor is a liver selective, reversible competitive inhibitor of HMG-CoA reductase, the rate limiting step in cholesterol biosynthesis. Lipitor monotherapy resulted in a reduction of LDL cholesterol by up to 60%. Lipitor is about 2-4 times more potent, on a dosage basis, than Simvastatin. The superior properties of Lipitor can be attributed to its greater uptake and longer duration of action in the liver. In addition to its effects on cholesterol, Lipitor is also effective in lowering triglycerides. While the mechanism is not clear, two theories proposed are: a) the decrease in cholesterol causes a concomitant increase in hepatic LDL-receptor activity (mostly B and E type) which results in a decrease in triglycerides through an increase in binding of triglycerides to VLDL and LDL, and b) the decreased level of cholesterol impairs VLDL transport of triglycerides.

Chemical Properties

White Crystalline Powder

Uses

A selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia

Definition

ChEBI: An organic calcium salt composed of calcium cations and atorvastatin anions in a 1:2 ratio.

Biological Activity

Potent HMG-CoA reductase inhibitor (IC 50 = 8 nM). Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model.

Atorvastatin calcium Preparation Products And Raw materials

Raw materials

n-Butyllithium Magnesium Sodium borohydride Triethylborane (S)-(-)-2-ACETOXY-1,1,2-TRIPHENYLETHANOL

Preparation Products

Atorvastatin Acetonide Atorvastatin Ethyl Ester

Atorvastatin calcium Suppliers

Global( 665)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Jigs Chemical ltd	+919099003427	Gujarat, India	239	58	Inquiry
Cadila Pharmaceuticals Ltd	+91-7069076657 +91-7069076657	Ahmedabad, India	54	58	Inquiry
ANWITA APIS	+919000311012	Hyderabad, India	198	58	Inquiry
Apotex Pharmachem India Pvt Ltd	+91-8022891034 +91-8022891000	Karnataka, India	109	58	Inquiry
Chemeca Drugs Private Limited (Vegesna Laboratories Pvt Ltd)	+91-8924236065 +91-9951616502	AndhraPradesh, India	48	58	Inquiry
Anuh Pharma Ltd (SK GROUP)	+912266227575	Maharashtra, India	38	58	Inquiry
Hetero Drugs Limited	+91-4023704923 +91-4023704923	Telangana, India	296	58	Inquiry
Mankind Pharma Limited	+91-1146541111 +91-1146541111	New Delhi, India	23	58	Inquiry
Macleods Pharmaceuticals Limited	+91-2266762800 +91-2266762800	Maharashtra, India	116	58	Inquiry
Sun Pharmaceutical Industries Ltd	+91-2242244224 +91-2243244324	Maharashtra, India	108	58	Inquiry

Supplier	Advantage
Jigs Chemical ltd	58
Cadila Pharmaceuticals Ltd	58
ANWITA APIS	58
Apotex Pharmachem India Pvt Ltd	58
Chemeca Drugs Private Limited (Vegesna Laboratories Pvt Ltd)	58
Anuh Pharma Ltd (SK GROUP)	58
Hetero Drugs Limited	58
Mankind Pharma Limited	58
Macleods Pharmaceuticals Limited	58
Sun Pharmaceutical Industries Ltd	58

Atorvastatin calcium Spectrum

Atorvastatin calcium(134523-03-8)¹HNMR

134523-03-8(Atorvastatin calcium)Related Search:

Pitavastatin calcium PHENYL VALERATE Calcium Propionate Calcium carbide Calcium citrate

Diphenyl ether Calcium nitrite Calcium chloride Rosuvastatin calcium Phenyl salicylate

Pyrrolidine Polyvinylpyrrolidone 4-Isopropylaniline Calcium carbonate N-Vinyl-2-pyrrolidone

Calcium stearate N-Methyl-2-pyrrolidone Atorvastatin Cyclic (Fluorophenyl) Impurity

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ATORVASTATIN CALCIUM (3R,5R)-7-(2-(4-FLUOROPHENYL)-5-ISOPROPYL-3-PHENYL-4-(PHENYLCARBAMOYL)-1H-PYRROL-1-YL)-3,5-DIHYDROXYHEPTANOIC ACID CALCIUM (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3- (R,dR)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid Calcium 3S,5S-Atorvastatin Calcium Bis[(3R,5R)-3,5-dihydroxy-7-[2-(1-methylethyl)-3-[(phenylamino)carbonyl]-4-phenyl-5-(4-fluorophenyl)-1H-pyrrol-1-yl]heptanoic acid]calcium salt Bis[(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-yl]-3,5-dihydroxyheptanoic acid] calcium salt Bis[(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-1-pyrrolyl]-3,5-dihydroxyheptanoic acid] calcium salt YM-548 ATORVASTATINCALCUIM (3R ,5R )-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl) Pyrrol-1-yl]-3 ,5 -Dihydroheptanoic Acid, calcium salt (2:1) Trihydrate 3R ,5R )-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl) Pyrrol-1-yl]-3 ,5 ydroheptanoic Acid, calcium salt (2:1) Trihydrate Atorvastatin Calclum ATORVASTATIN CALCIUM MM(CRM STANDARD) ATORVASTATINE CADIUM Atorvastatinecalcium 1h-pyrrole-1-heptanoicacid,beta,delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methy calciumsalt(2:1),(r-(r*,r*))-lethyl)-3-phenyl-4-((phenylamino)carbonyl) ci-981 delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-betcalci1h-pyrrole-1-heptanoicaci pd134298-38a (bR,dR)-2-(4-Fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid 3S,5S-Atorvastatin Alorvastin calcium delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-bet calci1h-pyrrole-1-heptanoic acid AtorvastatinCaliciumsalt 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-.beta.,.delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt (2:1), (.beta.R,.delta.R)- (R,R)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoicacidhemicalciumsalt Atorvastatin hemicalcium salt beta,delta-dihydroxy--2-(4-fluorophenyl)-5-(1-Methylethyl)-3-phenyl-4-((phenylaMino)carbonyl)-calciun salt(2:1) Pyrrole-1-heptanoic acid (3R,5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl- 4-(Pheynylcarbamoyl)Pyrrol-1-yl]-3,5–Dihydroheptanoic Acid, calcium salt Atorvastatin c Atorvastatin Atorvastatin aMorphous atorvastatine calciuM salt CalciuM (3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbaMoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate (βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole-1-heptanoic Acid CalciuM Salt Atorvastatin HeMicalciuM Sortis Tahor Atorvastatin CalciuM API (3R, 5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(PheynylcarbaMoyl) Pyrrol-1-yl]-3, 5 -Dihydroheptanoic Acid, calciuM salt (2:1) Trihydrate (crystal) Atorvastatin-Ca-D5 O-OH Atorvastatin-CalciuM Salt-D5 atorvastatin calciuM delta-dihydroxy-2-(4-fluorophenyl)-5-(1-Methylethyl)-3-phenyl-4-((phenylaMino)carbonyl)-bet calci1h-pyrrole-1-heptanoic acid Alorvastin calciuM Atorvastation CalciuM AtorvastatinCalciuMseries (βR,δR)-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid,calcium salt (2:1) Atorvastatin calcium salt solution Atorvastatin, Calcium Salt - CAS 134523-03-8 - Calbiochem 1H-Pyrrole-1-heptanoicacid,2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-,calciumsalt(2:1),(βR,δR)- Calcium of atorvastatin Atovastadine CA Atorvastatin caL cium saL t trihydrate Atorvastatin Calciume