ChemicalBook > Product Catalog >API >Circulatory system drugs >Lipid regulating drugs >Rosuvastatin calcium
Rosuvastatin calcium
- CAS No.
- 147098-20-2
- Chemical Name:
- Rosuvastatin calcium
- Synonyms
- CRESTOR;ROSUVASTATIN CA;Rosuvastatin Calcium CRS;Rosuvastatin for system suitability CRS;BD-04;ZD4522;Rostar;S 4522;Fortius;Rosuvastadine
- CBNumber:
- CB9482678
- Molecular Formula:
- C22H30CaFN3O6S
- Molecular Weight:
- 523.63
- MOL File:
- 147098-20-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/27 13:31:27
| Melting point | 122°C |
|---|---|
| alpha | D24 +14.8° (c = 1.012 in 50% methanol) |
| storage temp. | 2-8°C |
| solubility | DMSO : 25 mg/mL (49.94 mM; Need ultrasonic)H2O : 1 mg/mL (2.00 mM; Need ultrasonic) |
| form | powder |
| color | white to beige |
| optical activity | [α]/D +12 to +18°, c = 1 in methanol: water (1:1) |
| λmax | 243nm(Phosphate buffer sol.)(lit.) |
| Merck | 14,8270 |
| InChIKey | JSVIQRTVYKCCOM-LMRKSJJTNA-N |
| SMILES | C(/C1=C(N=C(N(C)S(=O)(=O)C)N=C1C1C=CC(F)=CC=1)C(C)C)=C\[C@@H](O)C[C@@H](O)CC(=O)O.[Ca] |&1:24,27,r| |
| CAS DataBase Reference | 147098-20-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P261-P305+P351+P338 |
| RTECS | MJ9675070 |
| HS Code | 29350090 |
Rosuvastatin calcium price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1264 | Rosuvastatin calcium ≥98% (HPLC) | 147098-20-2 | 10MG | ₹10716.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1264 | Rosuvastatin calcium ≥98% (HPLC) | 147098-20-2 | 50MG | ₹43613.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1928 | Rosuvastatin Calcium Pharmaceutical Secondary Standard; Certified Reference Material | 147098-20-2 | 1G | ₹23739.23 | 2022-06-14 | Buy |
| TCI Chemicals (India) | R0180 | Rosuvastatin Calcium | 147098-20-2 | 200MG | ₹10300 | 2022-05-26 | Buy |
Rosuvastatin calcium Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Crystalline Solid
Uses
Rosuvastatin Calcium Salt is a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.
Definition
ChEBI: An organic calcium salt that is the hemicalcium salt of rosuvastatin.
General Description
Rosuvastatin calcium (ROS) has a molecular mass of 1001.14. ROS is a member of the "statins" group and is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
Mechanism of action
Rosuvastatin is a statin medication and a competitive inhibitor of the enzyme HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol biosynthesis.24 Rosuvastatin acts primarily in the liver, where decreased hepatic cholesterol concentrations stimulate the upregulation of hepatic low density lipoprotein (LDL) receptors which increases hepatic uptake of LDL. Rosuvastatin also inhibits hepatic synthesis of very low density lipoprotein (VLDL).44 The overall effect is a decrease in plasma LDL and VLDL.
Rosuvastatin calcium Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 862)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| SYNIX LABS | +919849178742 | Hyderabad, India | 108 | 58 | Inquiry |
| TRC FINE CHEMS | +91-7400278327 +91-8097105248 | Mumbai, India | 73 | 58 | Inquiry |
| SURYA LIFE SCIENCES LIMITED | +91-2646226290 +91-9428511112 | Gujarat, India | 62 | 58 | Inquiry |
| Siddhivinayakchemicals | +91-912225190111 +91-9819773074 | Mumbai, India | 42 | 58 | Inquiry |
| SEUTIC | +91-8309787199 +91-8309787199 | Hyderabad, India | 124 | 58 | Inquiry |
| Flax Laboratories | +91-9867665132 +91-9867665132 | Maharashtra, India | 44 | 58 | Inquiry |
| Vadivarhe Speciality Chemicals Limited | +91-9028832204 +91-9028832204 | Maharashtra, India | 38 | 58 | Inquiry |
| AARTIA KEM SCIENCE | +91-8291072530 +91-8291072530 | Maharashtra, India | 70 | 58 | Inquiry |
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Jigs Chemical ltd | 58 |
| SYNIX LABS | 58 |
| TRC FINE CHEMS | 58 |
| SURYA LIFE SCIENCES LIMITED | 58 |
| Siddhivinayakchemicals | 58 |
| SEUTIC | 58 |
| Flax Laboratories | 58 |
| Vadivarhe Speciality Chemicals Limited | 58 |
| AARTIA KEM SCIENCE | 58 |
| GLP Pharma Standards | 58 |
147098-20-2(Rosuvastatin calcium)Related Search:
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(+)-bis[7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3R,5S-dihydroxy-6(E)-heptenoic acid]calcium salt
calcium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethan-3-ylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate
ZD4522
(3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[N-methyl(n-methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-Hep
Rosuvastatin (as Ca salt)
ROSUVASTATIN, CALCIUM SALT
ROSUVASTATIN CALCIUM
Calcium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-y
(3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[N-methyl(n-methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-Heptenoic calcium
RosuvastatinCalcium&Z7,Z8,R3
7-{4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
Rosuvastatin CalciuM
(3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-Methylethyl)-2-[N-Methyl(n-Methylsulfonyl)aMino]-5-pyriMidinyl]-3,5-dihydroxy-6-Heptenoic calciuM
Rosuvastatin Calium
Fortius
Rostar
Rosuvastatin hemicalcium
S 4522
ZD 4522, Calcium Salt
Rosuvastain Calcium
rosuvastatin
Rosuvastatin CalciuM
(3R,5R,6E)-7-[4-(4-fluorophenyl)-2-(N-MethylMethanesulfonaMido)-6-(propan-2-yl)pyriMidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
(+)-(3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-Methyl-N-MethanesulfonylaMino)pyriMidin-5-yl]-3,5-dihydroxy-6(E)-heptenoic acid calciuM salt (2:1)
Rosuvastatin calciuM(Crestor)
Rosuvastatin CalciuM (AMorphous)
Rosuvastatin CalciuM (ForM A)
BD-04
(3R,5S,6E)-7-{4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid calcium salt
Rosuvastatin calcium Solution, 100ppm
RosuvastatinCalcium>
Rosuvastatin Impurity 116
Rosuvastatin CaL
Rosuvastatin for system suitability
Calcium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate
Rosuvastatin calcium USP/EP/BP
Rosuvastatin Calcium，Rusuvastatin Calcium
(3R,5S,6E)-7-{4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
Rosuvastatin S-Isomer
Rosuvastatin-d3 Calcium Salt
Rosuvastatin Calcium (Y0001719)
Rosuvastatin calciumQ: What is
Rosuvastatin calcium Q: What is the CAS Number of
Rosuvastatin calcium Q: What is the storage condition of
Rosuvastatin calcium Q: What are the applications of
Rosuvastatin calcium
Rosuvastatin for system suitability (Y0001721)
Rosuvastatin Calcium (1606015)
(+/-)-Fargesin
6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, calcium salt (2:1), (3R,5S,6E)-
(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl])-3,5-dihydroxyhept-6-enoic acid hemicalcium salt
Rosuvastatin Calcium(W.S)
ZD 4522 Calcium
ROSUVASTATIN CALCIUM (ROSUVASTATIN HEMICALCIUM)
Rosuvastadine
ROSUVASTATIN CA
CRESTOR
Rosuvastatin for system suitability CRS
Rosuvastatin Calcium CRS
(E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
Rosuvastatin Calcium Salt CRS
Rosuvastatin Calcium
(3R,5S,6E)-7-{4-(4-Fluorophenyl)-6-isopropyl-2- [methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5- dihydroxyhept-6-enoic acid calcium salt
Rosuvastatin Calcium (BP)
(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid, calcium salt