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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Lipid regulating drugs >Rosuvastatin calcium

Rosuvastatin calcium

Rosuvastatin calcium Structure
  • ₹10300 - ₹43613.93
  • Product name: Rosuvastatin calcium
  • CAS: 147098-20-2
  • MF: C22H30CaFN3O6S
  • MW: 523.63
  • EINECS:627-028-1
  • MDL Number:MFCD04112702
  • Synonyms:(+)-bis[7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3R,5S-dihydroxy-6(E)-heptenoic acid]calcium salt;calcium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethan-3-ylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate;ZD4522;(3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[N-methyl(n-methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-Hep;Rosuvastatin (as Ca salt);ROSUVASTATIN, CALCIUM SALT;ROSUVASTATIN CALCIUM;Calcium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-y
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • 200MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberR0180
  • Product descriptionRosuvastatin Calcium
  • Packaging200MG
  • Price₹10300
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1264
  • Product descriptionRosuvastatin calcium ≥98% (HPLC)
  • Packaging10MG
  • Price₹10716.75
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1928
  • Product descriptionRosuvastatin Calcium Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹23739.23
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1264
  • Product descriptionRosuvastatin calcium ≥98% (HPLC)
  • Packaging50MG
  • Price₹43613.93
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) R0180 Rosuvastatin Calcium 200MG ₹10300 2022-05-26 Buy
Sigma-Aldrich(India) SML1264 Rosuvastatin calcium ≥98% (HPLC) 10MG ₹10716.75 2022-06-14 Buy
Sigma-Aldrich(India) PHR1928 Rosuvastatin Calcium Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹23739.23 2022-06-14 Buy
Sigma-Aldrich(India) SML1264 Rosuvastatin calcium ≥98% (HPLC) 50MG ₹43613.93 2022-06-14 Buy

Properties

Melting point :122°C
alpha :D24 +14.8° (c = 1.012 in 50% methanol)
storage temp. :2-8°C
solubility :DMSO : 25 mg/mL (49.94 mM; Need ultrasonic)H2O : 1 mg/mL (2.00 mM; Need ultrasonic)
form :powder
color :white to beige
optical activity :[α]/D +12 to +18°, c = 1 in methanol: water (1:1)
λmax :243nm(Phosphate buffer sol.)(lit.)
Merck :14,8270
InChIKey :JSVIQRTVYKCCOM-LMRKSJJTNA-N
SMILES :C(/C1=C(N=C(N(C)S(=O)(=O)C)N=C1C1C=CC(F)=CC=1)C(C)C)=C\[C@@H](O)C[C@@H](O)CC(=O)O.[Ca] |&1:24,27,r|
CAS DataBase Reference :147098-20-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs. Rosuvastatin is an HMG-CoA reductase inhibitor (IC50 = 5 nM). It is a fully-synthetic inhibitor that is designed to maximize the points of contact with, and inhibition of, HMG-CoA reductase. Rosuvastatin reduces low-density lipoprotein and C-reactive protein and increases high-density lipoprotein in clinical trials.

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