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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Lipid regulating drugs >Pitavastatin calcium

Pitavastatin calcium

Pitavastatin calcium Structure
  • ₹0
  • Product name: Pitavastatin calcium
  • CAS: 147526-32-7
  • MF: C25H26CaFNO4
  • MW: 463.56
  • EINECS:807-641-2
  • MDL Number:MFCD01937979
  • Synonyms:Pitavasttin Calcium;Pitavastatin Calcium /NK-104;(+)-Monocalciunbis{(3r,5s,6e)-7-[2-cyclopropyl-4-(4-fluorophenyl-3-quinolyl]-3,5-dihydroxy-6-heptenotate};Pitavastatin calciuM(Livalo);Calcium (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl)-3,5-dihydroxyhept-6-enoate;(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid,calcium salt (2:1);NK-104 Calcium;Pitavastatin CalciuM DISCONTINUED
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :>138oC (dec.)
alpha :D20 +23.1° (c = 1.00 in acetonitrile/water)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White to Off-White
Stability :Hygroscopic
InChIKey :ADXNRJCYUMOXPZ-MNGIKBOWNA-N
SMILES :C(/C1C(C2CC2)=NC2C=CC=CC=2C=1C1C=CC(F)=CC=1)=C\[C@@H](O)C[C@@H](O)CC(=O)O.[Ca] |&1:22,25,r|
CAS DataBase Reference :147526-32-7(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.

Description

The statins are a family of compounds that inhibit 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, a pivotal enzyme in cholesterol biosynthesis. Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki = 1.7 nM). It lowers both total cholesterol and low density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions. Moreover, pitavastatin causes atherosclerosis regression in humans with subclinical carotid atherosclerosis and improves cardiac function and survival in a rat model of hypertensive heart failure.

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Suppliers and manufacturers

PANCHSHEEL ORGANICS LTD Lupin Ltd Rivashaa Agrotech Biopharma Pvt. Ltd. Zydus Lifesciences Ltd. Hetero Drugs Limited Nosch Labs Pvt Ltd Enaltec Labs Pvt Ltd Solara Active Pharma Sciences Ltd SynZeal Research Pvt Ltd Pharmaffiliates Analytics and Synthetics P. Ltd