Simvastatin
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- ₹3294 - ₹31020
- Product name: Simvastatin
- CAS: 79902-63-9
- MF: C25H38O5
- MW: 418.57
- EINECS:616-751-8
- MDL Number:MFCD00072007
- Synonyms:(1s-(1-alpha,3-dro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenyleste ;7-beta,8-beta(2s*,4s*),8a-beta))-alph ;[1S-[1α，3α，7β，8β(2S^<*>^，4S^<*>^)，8αβ]-2，2-Dimethylbutanoic acid 1，2，3，7，8，8α-hexahydro-3，7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-y1)ethyl]-1-naphthyl ester;Lodaiès;[(1S,3R,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoat;Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro- 4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1-alpha,3-alpha,7- beta,8-beta(2S*,4S*),8a-beta));[8-[2-(4-Hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl]2,2-dimethylbutanoate;2,2-Dimethylbutyric acid (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalene-1-yl ester
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Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
- ottokemi
Package
- 5MG
- 10MG
- 25MG
- 50MG
- 100MG
- 1gm
- 1G
- ManufacturerTCI Chemicals (India)
- Product numberS0509
- Product descriptionSimvastatin
- Packaging100MG
- Price₹3300
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberS0509
- Product descriptionSimvastatin
- Packaging1G
- Price₹5900
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberS6196
- Product descriptionSimvastatin ≥97% (HPLC), solid
- Packaging5MG
- Price₹4189.28
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberPHR1438
- Product descriptionSimvastatin Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging1G
- Price₹9103.83
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number38956
- Product descriptionSimvastatin analytical standard
- Packaging10MG
- Price₹12037.4
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberS6196
- Product descriptionSimvastatin ≥97% (HPLC), solid
- Packaging25MG
- Price₹18597.35
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number567020
- Product descriptionSimvastatin - CAS 79902-63-9 - Calbiochem A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation.
- Packaging50MG
- Price₹31020
- Updated2022-06-14
- Buy
- Manufacturerottokemi
- Product number S 7491
- Product descriptionSimvastatin, ≥97% (HPLC)
- Packaging100mg
- Price₹3294
- Updated2022-05-26
- Buy
- Manufacturerottokemi
- Product number S 7491
- Product descriptionSimvastatin, ≥97% (HPLC)
- Packaging1gm
- Price₹5769
- Updated2022-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | S0509 | Simvastatin | 100MG | ₹3300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | S0509 | Simvastatin | 1G | ₹5900 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | S6196 | Simvastatin ≥97% (HPLC), solid | 5MG | ₹4189.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1438 | Simvastatin Pharmaceutical Secondary Standard; Certified Reference Material | 1G | ₹9103.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 38956 | Simvastatin analytical standard | 10MG | ₹12037.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S6196 | Simvastatin ≥97% (HPLC), solid | 25MG | ₹18597.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 567020 | Simvastatin - CAS 79902-63-9 - Calbiochem A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. | 50MG | ₹31020 | 2022-06-14 | Buy |
| ottokemi | S 7491 | Simvastatin, ≥97% (HPLC) | 100mg | ₹3294 | 2022-05-26 | Buy |
| ottokemi | S 7491 | Simvastatin, ≥97% (HPLC) | 1gm | ₹5769 | 2022-05-26 | Buy |
Properties
Melting point :127-132 °C (lit.)
alpha :D25 +292° (c = 0.5% in acetonitrile)
Boiling point :564.9±50.0 °C(Predicted)
Density :1.11±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL
pka :13.49±0.40(Predicted)
form :solid
color :white
optical activity :[α]/D +275±25°, c = 1 in acetonitrile
Merck :14,8539
BCS Class :2
Stability :Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
CAS DataBase Reference :79902-63-9(CAS DataBase Reference)
NIST Chemistry Reference :Simvastatin(79902-63-9)
EPA Substance Registry System :Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester (79902-63-9)
alpha :D25 +292° (c = 0.5% in acetonitrile)
Boiling point :564.9±50.0 °C(Predicted)
Density :1.11±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL
pka :13.49±0.40(Predicted)
form :solid
color :white
optical activity :[α]/D +275±25°, c = 1 in acetonitrile
Merck :14,8539
BCS Class :2
Stability :Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
CAS DataBase Reference :79902-63-9(CAS DataBase Reference)
NIST Chemistry Reference :Simvastatin(79902-63-9)
EPA Substance Registry System :Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester (79902-63-9)
Safety Information
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| Signal word: | Warning | ||||||||||||
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Description
Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor with anti-proliferative properties. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Mechanistic studies suggest that Simvastatin decreases CDK4 and CDK2 kinase activities and represses high glucose-induced Rho A (Rho GTPase)/p21 signaling in mesangial cells. Simvastatin also potentiates apoptosis in human myeloid leukemia cells via the suppression of TNF-induced NF-κB activation (IC50 ~ 13 M).More related product prices
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