Pravastatin manufacturers and suppliers in india

Pravastatin

Properties

Melting point:: 171.2-173 °C

Boiling point:: 634.5±55.0 °C(Predicted)

Density: 1.21±0.1 g/cm3(Predicted)

storage temp.: Sealed in dry,Room Temperature

solubility: H₂O: 19 mg/mL

pka: 4.31±0.10(Predicted)

form: powder

color: white

Safety Information

Symbol(GHS): GHS08,GHS09

Signal word: Danger

Hazard statements: H350-H360--H410

Precautionary statements: P273-P260-P314-P501

Hazard Codes: F,C

Risk Statements: 11-34

Safety Statements: 16-26-36/37/39-45

WGK Germany: 2

RTECS: QJ7185000

Use

Pravastatin, sodium 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoate (Pravachol), is the most rapid actingof the three HMG-CoA reductase inhibitor drugs, reachinga peak concentration in about 1 hour. The sodium salt of theβ-hydroxy acid is more hydrophilic than the lactone forms ofthe other two agents, which may explain this property. In addition,the open form of the lactone ring contributes to a morehydrophilic agent, which, in turn, results in less CNS penetration.This explains, in part, why pravastatin has fewer CNSside effects than the more lipophilic lactone ester of this classof agents. Absorption of pravastatin following oral administrationcan be inhibited by resins such as cholestyramine becauseof the presence of the carboxylic acid function on thedrug. The lactone forms of lovastatin and simvastatin are lessaffected by cholestyramine.