PHA 767491 HYDROCHLORIDE
PHA 767491 HYDROCHLORIDE
- CAS:
- 845714-00-3
- MF:
- C12H11N3O
- MW:
- 213.24
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Properties
- Density
- 1.287
- storage temp.
- Desiccate at RT
- solubility
- insoluble in H2O; insoluble in EtOH; ≥10.65 mg/mL in DMSO
- form
- solid
- Stability:
- Hygroscopic
Safety Information
Use
Cdc7 kinase is a key regulator of the S-phase of the cell cycle. It is known to promote the activity of DNA replication origins in eukaryotic organisms. Inhibition of Cdc7 kinase causes blockade of DNA synthesis in human cell lines. Tumor cells are then funneled into the apoptotic pathway in a p53-independent manner. Pharmacological inhibition of Cdc7 kinase can be an effective strategy for the development of oncologic therapeutics useful for treatment of cancers. PHA 767491 HYDROCHLORIDE is a potent inhibitor of Cdc7 kinase with an IC50 value of 10 nM in the presence of 1.5 μM ATP. At 10 μM, PHA 767491 HYDROCHLORIDE induces apoptotic cell death in multiple cancer cell types. PHA 767491 HYDROCHLORIDE also inhibits Cdk9, a kinase involved in the phosphorylation of RNA polymerase II and in transcriptional regulation of gene expression, with an IC50 value of 34 nM.[Cayman Chemical]
0 India supplier list of "PHA 767491 HYDROCHLORIDE"
- Product Name:PHA-767491(HCl)
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:PHA 767491 HYDROCHLORIDE
- Products Intro:Purity: >=99% | Package: 1.8KG;9.8USD
- Company Type: Trader
- Country/Region: CHINA
$9.80/ 1.8KG
- Product Name:PHA 767491 HYDROCHLORIDE
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
- Product Name:PHA-767491 PHA767491 Dihydrochloride Salt
- Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: PHA-767491HCL
- Company Type: Trader
- Country/Region: CHINA
- Main Products: sarms
- Product Name:PHA-767491
- Products Intro:Purity: NLT 98% | CustNote: MC574064
- Company Type: Manufacturer
- Country/Region: CHINA
- Main Products: 2432-11-3,1052686-50-6,2198-53-0,3769-42-4,83647-42-1
- Product Name:PHA-767491；CAY10572;PHA 767491;PHA767491
- Products Intro:Package: 1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Reagent
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
- Product Name:PHA 767491 HYDROCHLORIDE
- Products Intro:Purity: 99% | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Peptide Chemical,Heterocyclic compound,Organoboron Compound,Linker
- Product Name:PHA 767491
- Products Intro:Purity: 0 | Package: 1g; 5g; 25g; 1kg; 5kg; 25kg | CustNote: 0
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmaceutical intermediate
- Product Name:PHA-767491
- Products Intro:Purity: >=98% | Package: $209.9/5mg;$940.9/25mg;$3385.9/100mg;Bulk package | CustNote: 98%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
- Product Name:PHA-767491(HCl)
- Products Intro:Purity: 0.98 | Package: 10G:100G
- Company Type: Trader
- Country/Region: CHINA
- Main Products: MRTX1133,(cas:2055858-27-8)1,1′-Sulfinylbis[3,5-difluorobenzene,(cas:17220-38-1) 3,4-Diaminofurazane,Mirogabalin besylate,AK2292