ROLITETRACYCLINE
ROLITETRACYCLINE
- CAS:
- 751-97-3
- MF:
- C27H33N3O8
- MW:
- 527.57
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Properties
- Melting point:
- 163.5°C
- Boiling point:
- 608.16°C (rough estimate)
- Density
- 1.2902 (rough estimate)
- refractive index
- 1.7120 (estimate)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Very Slightly)
- form
- Solid
- pka
- pKa 7.4 (Uncertain)
- color
- Very Dark Red to Very Dark Brown
- Water Solubility
- >20g/L(21 ºC)
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 1
- RTECS
- QI9150000
Use
Rolitetracycline, launched in the late 1950s, was the first of the semi-synthetic tetracyclines. Rolitetracycline is formed by a Mannich condensation of formaldehyde and pyrrolidine with tetracycline. Rolitetracycline is a pro-drug of tetracycline, in which the pyrrolidine moiety improves bioavailability compared with tetracycline. Rolitetracycline has broad spectrum Gram positive activity in vivo, but pH instability limits use to parenteral administration. The intrinsic in vitro activity and SARs for this region of the tetracycline molecule have not been extensively investigated.
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