Sulindac
Sulindac
- CAS:
- 38194-50-2
- MF:
- C20H17FO3S
- MW:
- 356.41
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Properties
- Melting point:
- 182-185°C
- Boiling point:
- 581.6±50.0 °C(Predicted)
- Density
- 1.2581 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Very slightly soluble in water, soluble in methylene chloride, sparingly soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.
- pka
- pKa (25°) 4.7
- form
- Solid
- color
- Light yellow to Brown
- Water Solubility
- Soluble in water, methanol, ethanol.
- λmax
- 327nm(0.05mol/L methanolic HCl)(lit.)
- Merck
- 14,8982
Safety Information
- Symbol(GHS)
GHS06,GHS08
- Signal word
- Danger
- Hazard statements
- H301-H317-H334-H361
- Precautionary statements
- P261-P280-P284-P301+P330+P331+P310-P304+P340-P342+P311
- Hazard Codes
- Xn
- Risk Statements
- 22-63-42/43
- Safety Statements
- -
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- NK8226000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29309090
Use
Sulindac, (Z)-5-fluoro-2-methyl-1-([p-(methylsulfinyl)phenyl]methylene)-1H-indene-3-acetic acid (Clinoril), isan NSAID prodrug that contains a chiral sulfoxide moietybut is marketed as the racemate because it undergoes invivo reduction by the hepatic enzymes into its achiral, activemetabolite, methyl sulfide that exhibits potent andnonselective COX inhibition similar to indomethacin.The parent sulfoxide has a plasma half-life of 8 hours, andthe active methyl sulfide metabolite is 16.4 hours. The morepolar and inactive sulfoxide is virtually the only form excretedinto the renal tubules, thus sulindac is believed to haveminimal nephrotoxicity associated with indomethacin. Thelong half-life of sulindac is caused by the extensive enterohepaticcirculation and reactivation of the inactive sulfoxideexcreted. Coadministration of aspirin is contraindicated becauseit considerably reduces the sulfide blood levels. Carefulmonitoring of patients with a history of ulcers is recommended.Gastric bleeding, nausea, diarrhea, dizziness, andother adverse effects have been noted with sulindac, but witha lower frequency than with aspirin. Sulindac is recommendedfor RA, OA, and ankylosing spondylitis.
7 India supplier list of "Sulindac"
- Product Name:Sulindac
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Sulindac
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Sulindac
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Sulindac
- Products Intro:Brand:sigma aldrich | Product Number:PHR3359 | Purity:certifiedreferencematerial,pharmaceuticalsecondarystandard
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Sulindac
- Products Intro:Brand:synzeal | Product Number:578503539
- Company Type: Trader
- Country/Region: INDIA