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γ-Secretase Inhibitor XXI

γ-Secretase Inhibitor XXI Structure
  • ₹21780 - ₹37710
  • Product name: γ-Secretase Inhibitor XXI
  • CAS: 209986-17-4
  • MF: C27H24F2N4O3
  • MW: 490.5
  • EINECS:-0
  • MDL Number:
  • Synonyms:N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide;CoMpound E (secretase inhibitor);DuPont E;g-Secretase Inhibitor XXI;γ-Secretase Inhibitor BZ;γ-Secretase Inhibitor XXI;(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S,Z)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide;(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • Sigma-Aldrich
  • Sigma-Aldrich(India)

Package

  • 500μG
  • 1MG
  • 250μG
  • ManufacturerSigma-Aldrich
  • Product number5.30509
  • Product descriptionStemSelect Compound E - CAS 209986-17-4 - Calbiochem
  • Packaging250μG
  • Price₹21780
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number5.30509
  • Product descriptionStemSelect Compound E - CAS 209986-17-4 - Calbiochem
  • Packaging250μG
  • Price₹21780
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number565790
  • Product descriptionγ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem This g-secretase inhibitor, CAS 209986-17-4, is a cell-permeable, potent, selective, non-transition-state analog inhibitor of γ-secretase and Notch pr
  • Packaging1MG
  • Price₹35820.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number565790
  • Product descriptionγ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem This g-secretase inhibitor, CAS 209986-17-4, is a cell-permeable, potent, selective, non-transition-state analog inhibitor of γ-secretase and Notch pr
  • Packaging500μG
  • Price₹37710
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich 5.30509 StemSelect Compound E - CAS 209986-17-4 - Calbiochem 250μG ₹21780 2022-06-14 Buy
Sigma-Aldrich(India) 5.30509 StemSelect Compound E - CAS 209986-17-4 - Calbiochem 250μG ₹21780 2022-06-14 Buy
Sigma-Aldrich(India) 565790 γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem This g-secretase inhibitor, CAS 209986-17-4, is a cell-permeable, potent, selective, non-transition-state analog inhibitor of γ-secretase and Notch pr 1MG ₹35820.01 2022-06-14 Buy
Sigma-Aldrich(India) 565790 γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem This g-secretase inhibitor, CAS 209986-17-4, is a cell-permeable, potent, selective, non-transition-state analog inhibitor of γ-secretase and Notch pr 500μG ₹37710 2022-06-14 Buy

Properties

Boiling point :778.6±60.0 °C(Predicted)
Density :1.31
storage temp. := -70C
solubility :Soluble in DMSO
form :Liquid
pka :12.54±0.40(Predicted)
color :White to off-white
Sensitive :Light Sensitive

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

γ-Secretase is a multimeric aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. Two well-known substrates are the carboxyl-terminal fragments (CTFs) of the receptor Notch, which has key roles in development, and that of amyloid precursor protein (APP), which is important in Alzheimer’s disease. Compound E is a potent, cell-permeable, and selective inhibitor of γ-secretase, blocking the cleavage of both APP and Notch CTFs with IC50 values of ~0.3 nM. Compound E induces neuronal differentiation, impairs ovarian folliculogenesis, and suppresses thymocyte development by preventing Notch activation by γ-secretase.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
γ-Secretase-IN-1
₹129.00 /1mg
γ-Secretase-IN-1 CAS:209986-17-4
ATK CHEMICAL COMPANY LIMITED Zhejiang J&C Biological Technology Co.,Limited Nextpeptide Inc InvivoChem LEAP CHEM CO., LTD. Nantong HI-FUTURE Biology Co., Ltd. Aladdin Scientific Chuzhou KeMail Chemical Technology Co., Ltd Carbosynth