DIBENZAZEPINE
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- ₹11506.98 - ₹46374.3
- Product name: DIBENZAZEPINE
- CAS: 209984-56-5
- MF: C26H23F2N3O3
- MW: 463.48
- EINECS:
- MDL Number:MFCD12828734
- Synonyms:DIBENZAZEPINE;N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide;Dibenzazepine (Deshydroxy LY 411575);YO01027;γ-Secretase Inhibitor XX;YO-01027/Dibenzazepine/LY 411575;(2S)-2-[2-(3,5-Difluorophenyl)acetaMide]-N-[(7S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[B,D]azepin-7-;(S)-2-(2-(3,5-Difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7
4 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- 25MG
- 5MG
- 500μG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0649
- Product descriptionDeshydroxy LY-411575 ≥98% (HPLC)
- Packaging5MG
- Price₹11506.98
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number565789
- Product descriptionγ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ~72% in Tg257
- Packaging500μG
- Price₹29850
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number565789
- Product descriptionγ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ~72% in Tg257
- Packaging1MG
- Price₹37040
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0649
- Product descriptionDeshydroxy LY-411575 ≥98% (HPLC)
- Packaging25MG
- Price₹46374.3
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0649 | Deshydroxy LY-411575 ≥98% (HPLC) | 5MG | ₹11506.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 565789 | γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ~72% in Tg257 | 500μG | ₹29850 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 565789 | γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ~72% in Tg257 | 1MG | ₹37040 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0649 | Deshydroxy LY-411575 ≥98% (HPLC) | 25MG | ₹46374.3 | 2022-06-14 | Buy |
Properties
Melting point :257-259?C
Boiling point :801.3±65.0 °C(Predicted)
Density :1.35
storage temp. :-20°C
solubility :DMSO: soluble15mg/mL, clear
form :White solid
pka :12.76±0.20(Predicted)
color :white to beige
InChIKey :QSHGISMANBKLQL-OWJWWREXSA-N
Boiling point :801.3±65.0 °C(Predicted)
Density :1.35
storage temp. :-20°C
solubility :DMSO: soluble15mg/mL, clear
form :White solid
pka :12.76±0.20(Predicted)
color :white to beige
InChIKey :QSHGISMANBKLQL-OWJWWREXSA-N
Safety Information
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Description
γ-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Aβ), a 39- to 42-amino acid peptide which forms the amyloid plaques that are characteristic of Alzheimer’s disease. DBZ is a dipeptidic inhibitor of γ-secretase that potently blocks the cleavage of Notch into its active signaling effector, Notch intracellular domain, in human T cell lymphoma (SupT1) cells (IC50 = 1.7 nM). Within 4 hours after a single 100 μM/kg dose, DBZ demonstrates anti-Alzheimer activity in an APP transgenic mouse model characterized by high levels of Aβ40 by reducing Aβ40 levels by 71%.More related product prices
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