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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Proteases >Gamma-secretase inhibitors >FLI-06

FLI-06

FLI-06 Structure
  • ₹11528.63 - ₹46504.2
  • Product name: FLI-06
  • CAS: 313967-18-9
  • MF: C25H30N2O5
  • MW: 438.52
  • EINECS:-0
  • MDL Number:MFCD00330996
  • Synonyms:FLI-06;1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester;1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester FLI-06;3-QUINOLINECARBOXYLIC ACID, 1,4,5,6,7,8-HEXAHYDRO-2,7,7-TRIMETHYL-4-(4-NITROPHENYL)-5-OXO-, CYCLOHEXYL ESTER;FLI-06, 98%, a notch signaling and the early secretory pathway inhibitor;FLI-06 |FLI06;Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate;CS-1434
2 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0975
  • Product descriptionFLI-06 ≥98% (HPLC)
  • Packaging5MG
  • Price₹11528.63
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0975
  • Product descriptionFLI-06 ≥98% (HPLC)
  • Packaging25MG
  • Price₹46504.2
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0975 FLI-06 ≥98% (HPLC) 5MG ₹11528.63 2022-06-14 Buy
Sigma-Aldrich(India) SML0975 FLI-06 ≥98% (HPLC) 25MG ₹46504.2 2022-06-14 Buy

Properties

Melting point :199-202oC
Boiling point :597.5±50.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
form :powder
pka :0.78±0.70(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from that of brefeldin A. It inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER. Thus FLI-06 is the first small molecule acting at such an early stage in secretory traffic.1

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