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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Proteases >Gamma-secretase inhibitors >DAPT

DAPT

DAPT Structure
  • ₹17969.99 - ₹85225.23
  • Product name: DAPT
  • CAS: 208255-80-5
  • MF: C23H26F2N2O4
  • MW: 432.46
  • EINECS:
  • MDL Number:MFCD04974585
  • Synonyms:LY-374973, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester;N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethylester;SC-201315;(2S)-N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-2-phenylglycine tert-butyl ester;DAPT (enzyme inhibitor);GSI-IX;γ-Secretase Inhibitor IX;tert-butyl (2R)-[((2S)-2-{[(3,5-difluorophenyl)acetyl]aMino}propanoyl)aMino](phenyl)ethanoate
6 prices
Selected condition:

Brand

  • ALFA India
  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10mg
  • 25MG
  • ManufacturerALFA India
  • Product numberALF-J65864-MA
  • Product descriptionDAPT
  • Packaging10mg
  • Price₹24170
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberD4257
  • Product descriptionDAPT
  • Packaging25MG
  • Price₹18700
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number565770
  • Product descriptionγ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem Gamma-Secretase Inhibitor IX - CAS 208255-80-5, is a cell-permeable inhibitor of γ-secretase (Aβtotal IC?? = 115 nM, Aβ42 IC?? = 200 nM).
  • Packaging5MG
  • Price₹17969.99
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD5942
  • Product descriptionDAPT ≥98% (HPLC), solid
  • Packaging5MG
  • Price₹18932.93
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number565770
  • Product descriptionγ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem Gamma-Secretase Inhibitor IX - CAS 208255-80-5, is a cell-permeable inhibitor of γ-secretase (Aβtotal IC?? = 115 nM, Aβ42 IC?? = 200 nM).
  • Packaging10MG
  • Price₹25950
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD5942
  • Product descriptionDAPT ≥98% (HPLC), solid
  • Packaging25MG
  • Price₹85225.23
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ALFA India ALF-J65864-MA DAPT 10mg ₹24170 2022-05-26 Buy
TCI Chemicals (India) D4257 DAPT 25MG ₹18700 2022-05-26 Buy
Sigma-Aldrich(India) 565770 γ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem Gamma-Secretase Inhibitor IX - CAS 208255-80-5, is a cell-permeable inhibitor of γ-secretase (Aβtotal IC?? = 115 nM, Aβ42 IC?? = 200 nM). 5MG ₹17969.99 2022-06-14 Buy
Sigma-Aldrich(India) D5942 DAPT ≥98% (HPLC), solid 5MG ₹18932.93 2022-06-14 Buy
Sigma-Aldrich(India) 565770 γ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem Gamma-Secretase Inhibitor IX - CAS 208255-80-5, is a cell-permeable inhibitor of γ-secretase (Aβtotal IC?? = 115 nM, Aβ42 IC?? = 200 nM). 10MG ₹25950 2022-06-14 Buy
Sigma-Aldrich(India) D5942 DAPT ≥98% (HPLC), solid 25MG ₹85225.23 2022-06-14 Buy

Properties

alpha :+40.0~+47.0°(D/20℃)(c=0.5,DMSO)
Boiling point :612.2±55.0 °C(Predicted)
Density :1.213
storage temp. :2-8°C
solubility :DMSO: ~18 mg/mL
form :solid
pka :12.82±0.46(Predicted)
color :white
Sensitive :Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :DWJXYEABWRJFSP-XOBRGWDASA-N
CAS DataBase Reference :208255-80-5

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

γ-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Aβ), a 39- to 42-amino acid peptide which forms the amyloid plaques that are characteristic of Alzheimer’s disease. DAPT is an inhibitor of γ-secretase, blocking the production of total Aβ in human primary neuronal cultures with an IC50 value of 115 nM and Aβ42 with an IC50 value of 200 nM. DAPT is also effective in vivo, reducing brain levels of Aβ when given orally to mice that are transgenic for human APPV717F or to rats. Through its effects on γ-secretase, DAPT indirectly inhibits Notch, affecting cell signaling and cell differentiation.

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